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[精神分裂症中的自身抗体相关病理学]

[Autoantibody-Related Pathology in Schizophrenia].

作者信息

Shiwaku Hiroki, Takahashi Hidehiko

机构信息

Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

出版信息

Brain Nerve. 2023 Jun;75(6):763-767. doi: 10.11477/mf.1416202412.

Abstract

In the context of discovery of synaptic autoantibodies in patients with encephalitis, autoimmune psychosis with acute encephalopathy and psychosis as the main symptom has been proposed on the basis of those autoantibodies. Correspondingly, autoantibody-related mechanisms have also been proposed in schizophrenia. This paper outlines the relationship between schizophrenia and autoimmune psychosis by describing the relationship between synaptic autoantibodies and schizophrenia and our findings regarding anti-NCAM1 autoantibodies in schizophrenia.

摘要

在脑炎患者中发现突触自身抗体的背景下,基于这些自身抗体提出了以急性脑病和精神病为主要症状的自身免疫性精神病。相应地,在精神分裂症中也提出了自身抗体相关机制。本文通过描述突触自身抗体与精神分裂症之间的关系以及我们关于精神分裂症中抗NCAM1自身抗体的研究结果,概述了精神分裂症与自身免疫性精神病之间的关系。

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