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资源丰富环境下的HIV感染者的婴儿喂养:一种采用最佳实践的多学科方法,以最大程度降低风险

Infant feeding for people living with HIV in high resource settings: a multi-disciplinary approach with best practices to maximise risk reduction.

作者信息

Powell Anna M, Knott-Grasso Mary Ann, Anderson Jean, Livingston Alison, Rosenblum Nadine, Sturdivant Heather, Byrnes Kristen C, Martel Krista, Sheffield Jeanne S, Golden W Christopher, Agwu Allison L

机构信息

Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Division of Adolescent and Young Adult Health, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

出版信息

Lancet Reg Health Am. 2023 May 29;22:100509. doi: 10.1016/j.lana.2023.100509. eCollection 2023 Jun.

Abstract

Shared decision making for infant feeding in the context of HIV in high-resourced settings is necessary to acknowledge patient autonomy, meet increasing patient requests and address the changing reality of perinatal HIV care. In low-to middle-income countries (LMIC), where the majority of individuals living with HIV reside, persons with HIV are recommended to breastfeed their infants. In the setting of maternal anti-retroviral therapy (ART) use throughout pregnancy, viral suppression and appropriate neonatal post-exposure prophylaxis (PEP) use, updated information indicates that the risk of HIV transmission through breastmilk may be between 0.3 and 1%. While not endorsing or recommending breastfeeding, the United States' DHHS perinatal guidelines are similarly pivoting, stating that individuals should "receive patient-centred, evidence-based counselling on infant feeding options." Similar statements appear in the British, Canadian, Swiss, European, and Australasian perinatal guidelines. We assembled a multi-disciplinary group at our institution to develop a structured shared decision-making process and protocol for successful implementation of breastfeeding. We recommend early and frequent counselling about infant feeding options, which should include well known benefits of breastfeeding even in the context of HIV and the individual's medical and psychosocial circumstances, with respect and support for patient's autonomy in choosing their infant feeding option.

摘要

在资源丰富的环境中,针对感染艾滋病毒情况下的婴儿喂养进行共同决策,对于承认患者自主权、满足患者日益增加的要求以及应对围产期艾滋病毒护理不断变化的现实而言是必要的。在大多数艾滋病毒感染者居住的低收入和中等收入国家(LMIC),建议艾滋病毒感染者母乳喂养其婴儿。在整个孕期使用孕产妇抗逆转录病毒疗法(ART)、实现病毒抑制以及适当使用新生儿暴露后预防(PEP)的情况下,最新信息表明,通过母乳传播艾滋病毒的风险可能在0.3%至1%之间。虽然美国卫生与公众服务部(DHHS)的围产期指南不支持或推荐母乳喂养,但也在做出类似转变,指出个人应“接受以患者为中心、基于证据的关于婴儿喂养选择的咨询”。英国、加拿大、瑞士、欧洲和澳大利亚的围产期指南中也有类似表述。我们在本机构组建了一个多学科小组,以制定一个结构化的共同决策过程和方案,以便成功实施母乳喂养。我们建议尽早并频繁地就婴儿喂养选择进行咨询,这应包括母乳喂养的众所周知的益处,即使是在感染艾滋病毒的情况下,以及个人的医疗和心理社会状况,同时要尊重和支持患者自主选择婴儿喂养方式的权利。

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Brief Report: HIV-Positive and Breastfeeding in High-Income Settings: 5-Year Experience From a Perinatal Center in Germany.
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Front Immunol. 2022 Mar 4;13:822076. doi: 10.3389/fimmu.2022.822076. eCollection 2022.
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Plasma and Breast Milk Pharmacokinetics of Tenofovir Disoproxil Fumarate in Nursing Mother with Chronic Hepatitis B-Infant Pairs.
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