Li Ruidan, Liu Zheran, Huang Rendong, Chen Ye, Wei Zhigong, Wang Jingjing, He Ling, Pei Yiyan, Su Yonglin, Hu Xiaolin, Peng Xingchen
Department of Biotherapy and National Clinical Research Center for Geriatrics, Cancer Center West China Hospital Sichuan University Chengdu Sichuan China.
Hangzhou Linan Guorui Health Industry Investment Co., Ltd Hangzhou Zhejiang China.
MedComm (2020). 2023 Jun 5;4(3):e296. doi: 10.1002/mco2.296. eCollection 2023 Jun.
Frailty refers to a decline in the physiological functioning of one or more organ systems. It remained unclear whether variations in the trajectory of frailty over time were associated with subsequent cognitive change. The aim of the current study was to investigate the association between frailty trajectories and subsequent cognitive decline based on the Health and Retirement Study (HRS). A total of 15,454 participants were included. The frailty trajectory was assessed using the Paulson-Lichtenberg Frailty Index, while the cognitive function was evaluated using the Langa-Weir Classification. Results showed that severe frailty was significantly associated with the subsequent decline in cognitive function ( [95% CI] = -0.21 [-0.40, -0.03], = 0.03). In the five identified frailty trajectories, participants with mild frailty (inverted U-shaped, [95% CI] = -0.22 [-0.43, -0.02], = 0.04), mild frailty (U-shaped, [95% CI] = -0.22 [-0.39, -0.06], = 0.01), and frailty (β [95% CI] = -0.34 [-0.62, -0.07], = 0.01) were all significantly associated with the subsequent cognition decline in the elderly. The current study suggested that monitoring and addressing frailty trajectories in older adults may be a critical approach in preventing or mitigating cognitive decline, which had significant implications for healthcare.
衰弱是指一个或多个器官系统的生理功能下降。目前尚不清楚衰弱轨迹随时间的变化是否与随后的认知变化相关。本研究的目的是基于健康与退休研究（HRS）调查衰弱轨迹与随后认知衰退之间的关联。共纳入了15454名参与者。使用保尔森 - 利希滕贝格衰弱指数评估衰弱轨迹，同时使用兰加 - 韦尔分类法评估认知功能。结果显示，严重衰弱与随后的认知功能下降显著相关（[95%置信区间]= -0.21[-0.40，-0.03]，P = 0.03）。在确定的五条衰弱轨迹中，轻度衰弱（倒U形，[95%置信区间]= -0.22[-0.43，-0.02]，P = 0.04）、轻度衰弱（U形，[95%置信区间]= -0.22[-0.39，-0.06]，P = 0.01）以及衰弱（β[95%置信区间]= -0.34[-0.62，-0.07]，P = 0.01）的参与者均与老年人随后的认知衰退显著相关。本研究表明，监测和处理老年人的衰弱轨迹可能是预防或减轻认知衰退的关键方法，这对医疗保健具有重要意义。
