Laurent C, Hellström S, Stenfors L E
Am J Otolaryngol. 1986 May-Jun;7(3):181-6. doi: 10.1016/s0196-0709(86)80004-7.
Absorbable gelatin sponge, commonly used in otosurgery, was mixed with high-molecular-weight, highly concentrated hyaluronic acid. The mixture was introduced into the middle ear cavities of rats. The postoperative changes were evaluated by morphologic techniques after two months and three months. The middle ear cavity contained a loose mass of connective tissue with few cells, forming sail-like bridles between air-filled spaces. The filling material was easily detached from the surroundings. The structure of the middle ear mucosa and the tympanic membrane was well preserved. Compared with the findings in a previous study, in which absorbable gelatin sponge alone was used, the combination of gelatin sponge and hyaluronic acid caused significantly less structural alterations in the middle ear cavity. It is concluded that hyaluronic acid, a natural component in most tissues, markedly reduces the formation of the fibrous connective tissue known to develop in middle ear cavities filled with absorbable gelatin sponge alone.
可吸收明胶海绵常用于耳外科手术，将其与高分子量、高浓度的透明质酸混合。将该混合物引入大鼠中耳腔。术后两个月和三个月通过形态学技术评估变化情况。中耳腔内有一团疏松的结缔组织，细胞较少，在充满空气的间隙之间形成帆状束带。填充材料很容易与周围组织分离。中耳黏膜和鼓膜的结构保存良好。与之前仅使用可吸收明胶海绵的研究结果相比，明胶海绵和透明质酸的组合在中耳腔内引起的结构改变明显更少。得出的结论是，透明质酸作为大多数组织中的天然成分，能显著减少在仅填充可吸收明胶海绵的中耳腔内形成的纤维结缔组织。
