Krupala J L, Gianoli G J, Smith R A
Tulane University Medical School, Department of Otolaryngology-Head and Neck Surgery, New Orleans, Louisiana, USA.
Am J Otol. 1998 Sep;19(5):546-50.
The efficacy of hyaluronic acid (HA) foam in the prevention of middle ear adhesions and other structural abnormalities in guinea pigs undergoing experimental tympanoplasty was investigated. Postoperative changes in the middle ear were evaluated by light microscopy after 6 weeks. The presence of adhesions, diminution of airspace, new bone formation, tympanic membrane (TM) formation, and mucosal inflammation was characterized by an objective grading system. Results were compared to absorbable gelatin sponge (AGS) and a control group (no middle ear packing). The control group showed the best average scores for all parameters tested except for adhesion formation. However, these results were statistically significant only when compared with those of the AGS group for airspace preservation, new bone formation, and TM formation. Although the HA foam group showed better average results than did the AGS group for all parameters tested, none were statistically significant. Although HA foam appears to be a promising middle ear packing agent, further experimental trials are warranted before any firm conclusions may be made.
研究了透明质酸（HA）泡沫在预防豚鼠实验性鼓室成形术中中耳粘连及其他结构异常方面的疗效。术后6周通过光学显微镜评估中耳的变化。采用客观评分系统对粘连的存在、气腔缩小、新骨形成、鼓膜（TM）形成和黏膜炎症进行评估。将结果与可吸收明胶海绵（AGS）和对照组（无中耳填塞）进行比较。对照组在除粘连形成外的所有测试参数中平均得分最佳。然而，这些结果仅在与AGS组比较气腔保留、新骨形成和TM形成时具有统计学意义。尽管HA泡沫组在所有测试参数上的平均结果均优于AGS组，但均无统计学意义。尽管HA泡沫似乎是一种有前景的中耳填塞剂，但在得出任何确凿结论之前，仍需进行进一步的实验研究。
