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病例剖析：一名50岁女性复杂高级别子宫内膜癌的诊断与治疗，该肿瘤具有肝样、子宫内膜样、浆液性特征及体细胞源性卵黄囊瘤成分

Cracking the case: The diagnosis and treatment of a complex high-grade endometrial carcinoma with hepatoid, endometrioid, serous features and somatically derived yolk sac tumor component in a 50 year old female.

作者信息

O'Connell Cailin, Jang Sylvia, Monroig-Bosque Paloma, Alaniz Anne

机构信息

Texas A&M School of Engineering Medicine, United States.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, United States.

出版信息

Gynecol Oncol Rep. 2023 May 25;47:101207. doi: 10.1016/j.gore.2023.101207. eCollection 2023 Jun.

DOI:10.1016/j.gore.2023.101207
PMID:37288348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10241837/
Abstract

•Alpha-fetoprotein secreting tumors in gynecologic cancers have a broad differential.•Surgical pathology may provide a more comprehensive picture of tumor heterogeneity than initial biopsy.•Yolk Sac Tumor components intermixed with carcinoma points towards a somatic derivative rather than a collision tumor.•Alpha-fetoprotein can be trended over time to gauge response to treatment of cancers that produce the protein.

摘要

•妇科癌症中分泌甲胎蛋白的肿瘤有多种鉴别诊断。

•手术病理可能比初始活检更全面地呈现肿瘤异质性。

•卵黄囊瘤成分与癌混合提示为体细胞起源而非碰撞瘤。

•甲胎蛋白可随时间监测，以评估对产生该蛋白的癌症的治疗反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/d429b0d9d552/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/6c0768b774cd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/d81b3effa0d4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/d429b0d9d552/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/6c0768b774cd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/d81b3effa0d4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27c6/10241837/d429b0d9d552/gr3.jpg

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Cracking the case: The diagnosis and treatment of a complex high-grade endometrial carcinoma with hepatoid, endometrioid, serous features and somatically derived yolk sac tumor component in a 50 year old female.病例剖析：一名50岁女性复杂高级别子宫内膜癌的诊断与治疗，该肿瘤具有肝样、子宫内膜样、浆液性特征及体细胞源性卵黄囊瘤成分
Gynecol Oncol Rep. 2023 May 25;47:101207. doi: 10.1016/j.gore.2023.101207. eCollection 2023 Jun.
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Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours.老年女性生殖道卵黄囊瘤通常起源于体细胞上皮性肿瘤：体细胞源性卵黄囊瘤。
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本文引用的文献

1
Use of targeted therapy and immunotherapy for the treatment of yolk sac tumors in extragonadal pelvic sites: two case reports.靶向治疗和免疫治疗用于治疗性腺外盆腔部位卵黄囊瘤：两例病例报告
Gland Surg. 2021 Oct;10(10):3045-3052. doi: 10.21037/gs-21-663.
2
Pure primary yolk sac tumor of the endometrium tends to occur at a younger age: A case report and literature analysis.子宫内膜原发性单纯卵黄囊瘤倾向于发生在较年轻的年龄：一例病例报告及文献分析。
SAGE Open Med Case Rep. 2021 Jun 28;9:2050313X211027734. doi: 10.1177/2050313X211027734. eCollection 2021.
3
Extra-Hepatic Hepatoid Carcinomas in Female Reproductive System: Three Case-Reports with a Literature Review.
女性生殖系统肝外类癌：三例报告并文献复习
Cancer Manag Res. 2021 Feb 17;13:1625-1636. doi: 10.2147/CMAR.S288913. eCollection 2021.
4
Somatically Derived Yolk Sac Tumor of the Ovary in a Young Woman.年轻女性卵巢体腔上皮来源的卵黄囊瘤。
Int J Gynecol Pathol. 2021 May 1;40(3):296-300. doi: 10.1097/PGP.0000000000000673.
5
Biology and significance of alpha-fetoprotein in hepatocellular carcinoma.甲胎蛋白在肝细胞癌中的生物学特性及意义。
Liver Int. 2019 Dec;39(12):2214-2229. doi: 10.1111/liv.14223. Epub 2019 Sep 11.
6
Endometrial tumors with yolk sac tumor-like morphologic patterns or immunophenotypes: an expanded appraisal.具有卵黄囊瘤样形态学模式或免疫表型的子宫内膜肿瘤：扩大评估。
Mod Pathol. 2019 Dec;32(12):1847-1860. doi: 10.1038/s41379-019-0341-6. Epub 2019 Aug 2.
7
Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours.老年女性生殖道卵黄囊瘤通常起源于体细胞上皮性肿瘤：体细胞源性卵黄囊瘤。
Histopathology. 2016 Nov;69(5):739-751. doi: 10.1111/his.13021. Epub 2016 Aug 5.
8
Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma.具有内胚层-肠分化的原发性子宫内膜卵黄囊瘤伪装成转移性结直肠癌
Int J Gynecol Pathol. 2016 Jul;35(4):316-20. doi: 10.1097/PGP.0000000000000236.
9
Oncology biomarkers for gynecologic malignancies.妇科恶性肿瘤的肿瘤生物标志物
Front Biosci (Elite Ed). 2012 Jan 1;4(3):1097-110. doi: 10.2741/e444.
10
Ovarian yolk sac tumors in older women arising from epithelial ovarian tumors or with no detectable epithelial component.老年女性的卵巢卵黄囊瘤，来源于上皮性卵巢肿瘤或无明显上皮成分。
Int J Gynecol Pathol. 2011 Sep;30(5):442-51. doi: 10.1097/PGP.0b013e3182164386.