Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China.
Org Lett. 2023 Jun 23;25(24):4525-4529. doi: 10.1021/acs.orglett.3c01562. Epub 2023 Jun 8.
An oxidative azido-difluoromethylthiolation of alkenes by employing TMSN as the azide source and PhSOSCFH as the difluoromethylthiolation reagent is reported. The present method is characterized by good functional group tolerance, broad substrate scope, and short reaction time, thereby providing an efficient access to synthetically useful β-difluoromethylthiolated azides. Mechanistic studies indicate a radical pathway involved in the reaction.
本文报道了一种通过 TMSN 作为叠氮源、PhSOSCFH 作为二氟甲基硫代试剂，实现烯烃的氧化叠氮-二氟甲基硫代反应的方法。该方法具有良好的官能团耐受性、广泛的底物范围和较短的反应时间等特点，为合成有用的β-二氟甲基硫代叠氮化物提供了一种有效的方法。机理研究表明，该反应涉及自由基途径。
