Shah M V, Anderson L K, Bergman N A
Anaesthesia. 1986 Jun;41(6):586-8. doi: 10.1111/j.1365-2044.1986.tb13048.x.
There are conflicting reports of the effect of nitrous oxide on the oxyhaemoglobin dissociation curve. We have therefore determined P50 of haemoglobin in the presence of either nitrous oxide or nitrogen and studied the upper portion of the curve in greater detail. No significant differences in the oxyhaemoglobin dissociation curve were observed when nitrous oxide was substituted for nitrogen. The oxygen tensions measured in gas mixtures were not significantly different when determined simultaneously with a polarographic oxygen electrode and the mass spectrometer when nitrous oxide was used instead of nitrogen.
关于一氧化二氮对氧合血红蛋白解离曲线的影响，有相互矛盾的报道。因此，我们测定了在一氧化二氮或氮气存在下血红蛋白的P50，并更详细地研究了曲线的上部。用一氧化二氮替代氮气时，未观察到氧合血红蛋白解离曲线有显著差异。当使用一氧化二氮代替氮气时，用极谱氧电极和质谱仪同时测定气体混合物中的氧张力，结果无显著差异。
