Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.
Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.
Biomed Pharmacother. 2023 Aug;164:114967. doi: 10.1016/j.biopha.2023.114967. Epub 2023 Jun 6.
Lactoferrin (LF) is a protein found in several bodily fluids, such as milk. This protein has a diverse range of functions and is evolutionarily conserved. Lactoferrin is a multifunction protein with distinct biological abilities affecting mammals' immune structures. Reports indicated that the daily uptake of LF from dairy products is unsatisfactory in detecting further health-promoting abilities. Research has shown that it protects against infection, mitigates cellular senescence, and improves nutritional quality. Additionally, LF is being studied as a potential treatment for various diseases and conditions, including gastrointestinal issues and infections. Studies have also demonstrated its effectiveness against various viruses and bacteria. In this article, we'll look closer at the structure of LF and its various biological activities, including its antimicrobial, anti-viral, anti-cancer, anti-osteoporotic, detoxifying, and immunomodulatory properties. More specifically, the protective effect of LF against oxidative DNA damage was also clarified through its ability to abolish DNA damaging issues without interfacing with host genetic material. Fortification with LF protects mitochondria dysfunction syndromes via sustaining redox status and biogenesis and suppressing apoptosis and autophagy singling. Additionally, we'll examine the potential benefits of lactoferrin and provide an overview of recent clinical trials conducted to examine its use in laboratory and living models.
乳铁蛋白（LF）是一种存在于多种体液中的蛋白质，如牛奶。这种蛋白质具有多种功能，在进化上是保守的。乳铁蛋白是一种多功能蛋白，具有独特的生物学能力，影响哺乳动物的免疫结构。有报道称，从乳制品中每天摄取 LF 并不能充分检测到其进一步的促进健康的能力。研究表明，它具有抗感染、减轻细胞衰老和提高营养质量的作用。此外，LF 正在被研究作为治疗各种疾病和病症的潜在方法，包括胃肠道问题和感染。研究还表明它对各种病毒和细菌有效。在本文中，我们将更详细地研究 LF 的结构及其各种生物学活性，包括其抗菌、抗病毒、抗癌、抗骨质疏松、解毒和免疫调节特性。更具体地说，LF 通过消除 DNA 损伤问题而不与宿主遗传物质相互作用，阐明了其对氧化 DNA 损伤的保护作用。LF 的强化作用通过维持氧化还原状态和生物发生以及抑制凋亡和自噬信号来保护线粒体功能障碍综合征。此外，我们将研究乳铁蛋白的潜在益处，并概述最近进行的临床试验，以检查其在实验室和活体模型中的用途。
