Benzon H T, Toleikis J R, Shanks C, Ramseur A, Sloan T
Anesth Analg. 1986 Aug;65(8):843-8.
We investigated the appropriateness of the somatosensory evoked potentials (SSEPs) as an objective monitor of sensory blockade of the ulnar nerve by comparing the effects of saline and lidocaine infiltration of the ulnar nerve at the elbow, with and without epinephrine. The four treatments were administered in random order to each of eight volunteers who were asked to assess the intensity of sensory blockade on a 10-cm visual analogue scale (SVAS). Concomitantly, ulnar nerve SSEPs were recorded at the Erb's point, over the posterior spine at or rostral to C-7, and over the sensory cortex. All 16 of the saline and saline with epinephrine infiltrations resulted in SVAS scores of 1 or less. In contrast, all the lidocaine and lidocaine with epinephrine injections were associated with SVAS scores in excess of 8. With lidocaine this lasted 83 +/- 22 min, and the duration of lidocaine with epinephrine was 248 +/- 82 min. SSEP responses were considered abnormal when there were 15 min or more of a decrease in amplitude by 50% or more and an increase in latency by 15% or more. After plain lidocaine injection, all the amplitude measurements showed depression over 50%, with the exception of cortical measurements in one subject. Similarly, there were increased latencies at Erb's point and C-7 with lidocaine blocks. In contrast, change in cortical latency was seldom seen. Variable selection by multiple linear regression analysis of the six SSEP measurements gave a statistical model that sensory block duration (SVAS greater than or equal to 8) could be specified by the duration of the reduced C-7 amplitude (r = 0.96).(ABSTRACT TRUNCATED AT 250 WORDS)
我们通过比较在肘部尺神经注射生理盐水和利多卡因(有无肾上腺素)的效果,研究了体感诱发电位(SSEPs)作为尺神经感觉阻滞客观监测指标的适用性。将四种治疗方法随机施用于八名志愿者,要求他们在10厘米视觉模拟量表(SVAS)上评估感觉阻滞的强度。同时,在Erb点、C-7或其头侧的后脊柱以及感觉皮层记录尺神经SSEPs。所有16次生理盐水和含肾上腺素生理盐水注射导致的SVAS评分均为1或更低。相比之下,所有利多卡因和含肾上腺素利多卡因注射的SVAS评分均超过8。利多卡因的作用持续83±22分钟,含肾上腺素利多卡因的作用持续时间为248±82分钟。当振幅降低50%或更多且潜伏期增加15%或更多持续15分钟或更长时间时,SSEP反应被认为异常。注射普通利多卡因后,除一名受试者的皮层测量外,所有振幅测量均显示降低超过50%。同样,利多卡因阻滞时Erb点和C-7的潜伏期增加。相比之下,很少见到皮层潜伏期的变化。对六个SSEP测量值进行多元线性回归分析的变量选择得到一个统计模型,即感觉阻滞持续时间(SVAS大于或等于8)可由C-7振幅降低的持续时间确定(r = 0.96)。(摘要截断于250字)