Cunningham-Rundles C
Ann Allergy. 1986 Jul;57(1):31-5.
Secretory IgA is known to play a major role in the exclusion of foreign antigens from the systemic compartments. We have previously shown that IgA-deficient subjects can have large amounts of circulating immune complexes containing bovine antigens of dietary origin, presumably due to the defective secretory barrier. In these studies, we investigated whether the peak amount of immune complexes found after specific antigen challenge could be related to the level of serum or salivary IgA. Our data show that the peak of immune complex is not related to either serum or salivary IgA but that it is closely correlated to the titer of antibody to milk proteins. In addition, it appears that some individuals with only modest IgA deficits can have substantial mucosal permeability defects on milk challenge.
已知分泌型IgA在将外来抗原排除于全身腔室中起主要作用。我们之前已经表明，IgA缺陷的受试者可能有大量含有饮食来源牛抗原的循环免疫复合物，推测这是由于分泌屏障缺陷所致。在这些研究中，我们调查了特异性抗原激发后发现的免疫复合物峰值量是否可能与血清或唾液IgA水平相关。我们的数据表明，免疫复合物峰值与血清或唾液IgA均无关，但与牛奶蛋白抗体滴度密切相关。此外，似乎一些仅有适度IgA缺陷的个体在牛奶激发时可出现明显的黏膜通透性缺陷。
