Cunningham-Rundles C, Brandeis W E, Good R A, Day N K
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3387-9. doi: 10.1073/pnas.75.7.3387.
Twenty-two patients with selective IgA deficiency were studied for the presence of serum precipitins to bovine milk, bovine and fetal calf serum, and circulating immune complexes. Fifty-nine percent had circulating immune complexes, 50% had milk precipitins, 23% had precipitins to bovine serum, and 13% had precipitins to fetal calf serum. All patients with precipitating antibodies against milk or against bovine or fetal calf serum had circulating immune complexes and the precipitin titers correlated with the amount of circulating immune complexes. After one IgA-deficient patient had drunk 100 ml of milk, studies of sequential serum samples showed the presence of casein in the circulation at 60 min and the appearance of increasing amounts of immune complexes for 120 min. These findings are interpreted to indicated that in human beings the IgA system may provide a major barrier to absorption of immunogens from the gastrointestinal tract.
对22例选择性IgA缺乏患者进行了研究，检测其血清中针对牛乳、牛血清和胎牛血清的沉淀素以及循环免疫复合物。59%的患者有循环免疫复合物，50%有针对牛奶的沉淀素，23%有针对牛血清的沉淀素，13%有针对胎牛血清的沉淀素。所有针对牛奶或牛血清或胎牛血清产生沉淀抗体的患者都有循环免疫复合物，且沉淀素滴度与循环免疫复合物的量相关。一名IgA缺乏患者饮用100毫升牛奶后，对连续采集的血清样本进行研究发现，60分钟时循环中有酪蛋白存在，120分钟内免疫复合物的量不断增加。这些发现被解释为表明在人类中，IgA系统可能是胃肠道免疫原吸收的主要屏障。
