Park Hyunsun, Kim Jung Eun, Choi Jee Woong, Kim Do Young, Jang Yong Hyun, Lee Young, Jeon Jiehyun, Shin Hyun-Tae, Kim Min Sung, Shin Jung Won, Cho Sung Bin, Lew Bark-Lynn, Choi Gwang Seong
Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2023 Jun;35(3):205-216. doi: 10.5021/ad.22.167.
Alopecia areata (AA) is a chronic disease with an unpredictable course and can have a severe psychological impact on an individual.
To provide evidence and consensus-based statements regarding the treatment of patients with AA in Korea.
We searched for relevant studies from inception to May 2021 regarding the systemic treatment of AA. Evidence-based recommendations were also prepared. The evidence for each statement was graded and classified according to the strength of the recommendations. Hair experts from the Korean Hair Research Society (KHRS) voted on the statement, and an agreement of 75% or greater was considered as having reached consensus.
Current evidence supports the efficacy of systemic corticosteroids, oral cyclosporine monotherapy or combination with systemic corticosteroids, and oral Janus kinase inhibitors in severe AA patients. Systemic steroids may be considered for pediatric patients with severe AA. A consensus was achieved in three out of nine (33.3%), and one out of three (33.3%) statements pertaining to systemic treatment in adult and pediatric AA, respectively.
The present study produced up-to-date, evidence-based treatment guidelines for AA associated with the consensus obtained by experts based on the Korean healthcare system.
斑秃（AA）是一种病程不可预测的慢性疾病，会对个体产生严重的心理影响。
提供关于韩国斑秃患者治疗的循证和基于共识的声明。
我们检索了从开始到2021年5月有关斑秃系统治疗的相关研究。还制定了循证建议。根据建议的强度对每条声明的证据进行分级和分类。韩国毛发研究协会（KHRS）的毛发专家对声明进行投票，75%或更高的同意率被视为达成共识。
目前的证据支持全身用皮质类固醇、口服环孢素单药治疗或与全身用皮质类固醇联合使用，以及口服Janus激酶抑制剂对重度斑秃患者的疗效。对于重度斑秃的儿科患者可考虑使用全身用类固醇。在分别与成人和儿科斑秃系统治疗相关的九条声明中有三条（33.3%）、三条声明中有一条（33.3%）达成了共识。
本研究基于韩国医疗保健系统，结合专家达成的共识，制定了最新的、循证的斑秃治疗指南。
