Center S A, Castleman W, Roth L, Baldwin B H, Tennant B C
Am J Vet Res. 1986 Jun;47(6):1278-82.
Light microscopic and transmission electron microscopic changes were studied in the livers of 6 cats at 25 to 54 days after their extrahepatic bile ducts were experimentally obstructed. Histologic findings included various degrees of bile duct dilatation, ductular proliferation, and peribiliary fibrosis. Concentric layers of dense, birefringent connective tissue surrounded midsized bile ducts. The degrees of bile duct proliferation, hepatocellular degeneration, and bile retention were similar in each cat, but the amount of periductular connective tissue increased with chronicity of bile duct obstruction. Ultrastructural changes included marked swelling of endoplasmic reticulum and mitochondrial inner compartments, marked dilatation and distention of the canaliculi by bile casts, and numerical reduction of canalicular microvilli. Microvilli were often swollen and blunt. Mitochondria were swollen and long, and the cristae lacked normal distribution and density. Cytoplasmic accumulations of granular, electron-dense material and concentrically laminated arrays of material indicative of bile substances were also observed.
对6只猫实验性阻塞肝外胆管后25至54天的肝脏进行了光镜和透射电镜观察。组织学发现包括不同程度的胆管扩张、小胆管增生和胆管周围纤维化。中等大小的胆管被致密的双折射结缔组织同心层包围。每只猫的胆管增生、肝细胞变性和胆汁潴留程度相似，但胆管周围结缔组织的量随胆管阻塞的慢性化而增加。超微结构改变包括内质网和线粒体内腔明显肿胀、胆小管因胆栓而明显扩张和膨胀、胆小管微绒毛数量减少。微绒毛常肿胀且钝圆。线粒体肿胀且长，嵴缺乏正常分布和密度。还观察到细胞质中颗粒状、电子致密物质的积聚以及指示胆汁物质的同心层状物质排列。
