Mousavi Seyedeh Neda, Bahramfard Tooba, Rad Esmaeil Yousefi, Hosseinikia Mahboobe, Saboori Somayeh
Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Indian J Endocrinol Metab. 2023 Mar-Apr;27(2):96-104. doi: 10.4103/ijem.ijem_385_22. Epub 2023 Apr 14.
The positive correlation between serum levels of retinol binding protein 4 (RBP4) and gestational diabetes (GDM) has been proven in the previous meta-analysis on case-control studies. However, its association with serum levels of leptin is not studied in any meta-analysis. Therefore, we performed an updated systematic review of observational studies evaluating the association between serum RBP4 and leptin with the risk of GDM. A systematic search was performed on four databases, including PubMed, Scopus, Web of Science, and Google Scholar, up to March 2021. After screening and deleting duplicates, nine articles met our inclusion criteria. Studies had case-control and cohort design, and included 5074 participants with a mean age range between 18 and 32.65 years (2359 participants for RBP4 and 2715 participants for leptin). Interestingly, this meta-analysis revealed higher levels of RBP4 (OR=2.04; 95% CI: 1.37, 3.04) and leptin (OR=2.32; 95% CI: 1.39, 3.87) are significantly associated with the increased risk of overall GDM. The subgroup analysis approved the results based on the study design, trimester of pregnancy and serum/plasms to investigate the source of heterogeneity. The present meta-analysis determines serum leptin and RBP4 levels as predictors of GDM occurrence. However, studies included in this meta-analysis showed significant heterogeneity.
在之前关于病例对照研究的荟萃分析中，已证实血清视黄醇结合蛋白4（RBP4）水平与妊娠期糖尿病（GDM）之间存在正相关。然而，在任何荟萃分析中均未研究其与血清瘦素水平的关联。因此，我们对评估血清RBP4和瘦素与GDM风险之间关联的观察性研究进行了更新的系统评价。截至2021年3月，我们在四个数据库（包括PubMed、Scopus、Web of Science和谷歌学术）上进行了系统检索。在筛选并删除重复项后，有9篇文章符合我们的纳入标准。这些研究采用病例对照和队列设计，纳入了5074名参与者，平均年龄范围在18至32.65岁之间（RBP4相关研究有2359名参与者，瘦素相关研究有2715名参与者）。有趣的是，这项荟萃分析显示，较高水平的RBP4（OR = 2.04；95% CI：1.37，3.04）和瘦素（OR = 2.32；95% CI：1.39，3.87）与总体GDM风险增加显著相关。亚组分析根据研究设计、妊娠 trimester和血清/血浆来调查异质性来源，证实了该结果。本荟萃分析确定血清瘦素和RBP4水平为GDM发生的预测指标。然而，纳入本荟萃分析的研究显示出显著的异质性。 （注：原文中“trimester”翻译为“孕期”，这里保留英文是因为原文此处表述不太明确准确，可能是想表达“妊娠阶段”等意思，直接翻译为中文可能影响原意理解，结合上下文此处更倾向于保留英文让读者结合语境思考其准确含义；另外，原文中“plasms”疑似“plasma”拼写错误，翻译时按“血浆”翻译 ）
