Sun Haoying, Ma Jinzhu, Chen Yibo, Liu Ming
Department of Thyroid and Breast Surgery, The Affiliated Hospital of Inner Mongolia Medical University No. 1 Tongdaobei Street, Huimin District, Hohhot 010050, Inner Mongolia, China.
Int J Clin Exp Pathol. 2023 May 20;16(5):99-107. eCollection 2023.
This study aims to investigate the pathogenesis, clinical characteristics, diagnosis, treatment, and prognosis of primary thyroid lymphoma (PTL) for a better understanding of the disease and a more accurate PTL diagnosis, thereby preventing misdiagnosis and mistreatment.
The clinical manifestations, biochemical examination, ultrasound examination, imaging examination, pathologic examination, diagnosis, and treatment of four PLT patients admitted to the Department of Thyroid and Breast Surgery of the Affiliated Hospital of Inner Mongolia Medical University from January 2010 to December 2020 were retrospectively analyzed.
Diffuse large B-cell lymphoma (DLBCL) expressing cluster of differentiation 20 (CD20) were detected in all four PTL patients. Hashimoto's thyroiditis (HT) with increased anti-thyroglobulin antibodies (TGAb) occurred in two PTL patients, while antithyroid peroxidase autoantibody (TPOAb) was increased in three cases. All four patients underwent surgical and chemoradiotherapy treatments. Patients were without tumors during the follow-up ranging from 8 to 55 months.
PTL is a primary extranodal lymphoma of the thyroid and is mainly derived from B-cell non-Hodgkin's lymphoma. The pathogenesis of PTL remains unclear, but it is closely related to HT. Clinical diagnosis in this study was determined by either needle biopsy or surgical resection.
本研究旨在探讨原发性甲状腺淋巴瘤（PTL）的发病机制、临床特征、诊断、治疗及预后，以更好地了解该疾病并更准确地诊断PTL，从而防止误诊和误治。
回顾性分析2010年1月至2020年12月内蒙古医科大学附属医院甲状腺乳腺外科收治的4例PTL患者的临床表现、生化检查、超声检查、影像学检查、病理检查、诊断及治疗情况。
4例PTL患者均检测到表达分化簇20（CD20）的弥漫性大B细胞淋巴瘤（DLBCL）。2例PTL患者出现抗甲状腺球蛋白抗体（TGAb）升高的桥本甲状腺炎（HT），3例患者抗甲状腺过氧化物酶自身抗体（TPOAb）升高。4例患者均接受了手术及放化疗治疗。随访8至55个月期间患者无肿瘤复发。
PTL是甲状腺原发性结外淋巴瘤，主要来源于B细胞非霍奇金淋巴瘤。PTL的发病机制尚不清楚，但与HT密切相关。本研究中的临床诊断通过针吸活检或手术切除确定。
