The silent flucytosine shortage in Europe - not a distant problem.
作者信息
Sprute Rosanne, Duda Seraina, Liekweg Andrea, Simon Michaela, Cornely Oliver A
机构信息
Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
出版信息
Lancet Reg Health Eur. 2023 May 31;30:100658. doi: 10.1016/j.lanepe.2023.100658. eCollection 2023 Jul.
Abstract
摘要
相似文献
1
The silent flucytosine shortage in Europe - not a distant problem.欧洲氟胞嘧啶的隐性短缺——并非遥远的问题。
Lancet Reg Health Eur. 2023 May 31;30:100658. doi: 10.1016/j.lanepe.2023.100658. eCollection 2023 Jul.
2
Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution.CLSI 肉汤微量稀释法测定的野生型 MIC 分布和两性霉素 B、氟胞嘧啶和伊曲康唑及念珠菌属的流行病学折点值。
J Clin Microbiol. 2012 Jun;50(6):2040-6. doi: 10.1128/JCM.00248-12. Epub 2012 Mar 29.
3
Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine.新型隐球菌-格特隐球菌种复合体：两性霉素 B 和氟胞嘧啶野生型药敏终点分布及流行病学折点的国际研究。
Antimicrob Agents Chemother. 2012 Jun;56(6):3107-13. doi: 10.1128/AAC.06252-11. Epub 2012 Mar 5.
4
National and transnational drug shortages: a quantitative descriptive study of public registers in Europe and the USA.国家和跨国药物短缺：对欧洲和美国公共登记处的定量描述性研究。
BMC Health Serv Res. 2022 Jul 22;22(1):940. doi: 10.1186/s12913-022-08309-3.
5
New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae.通过酿酒酵母的化学基因组学分析揭示光滑念珠菌中氟胞嘧啶耐药的新机制。
PLoS One. 2015 Aug 12;10(8):e0135110. doi: 10.1371/journal.pone.0135110. eCollection 2015.
6
Amphotericin B and flucytosine in the treatment of candidal cystitis.两性霉素B与氟胞嘧啶治疗念珠菌性膀胱炎
Clin Pharm. 1982 Jul-Aug;1(4):349-52.
7
Pharmacokinetics of amphotericin B and flucytosine.两性霉素B与氟胞嘧啶的药代动力学
Postgrad Med J. 1979 Sep;55(647):667-70. doi: 10.1136/pgmj.55.647.667.
8
Absence of fungistatic antagonism between flucytosine and cytarabine in vitro and in vivo.氟胞嘧啶与阿糖胞苷在体内外均不存在抑菌拮抗作用。
J Antimicrob Chemother. 1987 Oct;20(4):523-7. doi: 10.1093/jac/20.4.523.
9
In vitro evaluation of combination of fluconazole and flucytosine against Cryptococcus neoformans var. neoformans.氟康唑与氟胞嘧啶联合用药对新型隐球菌新型变种的体外评价
Antimicrob Agents Chemother. 1995 Aug;39(8):1691-5. doi: 10.1128/AAC.39.8.1691.
10
Cryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.隐球菌性脑膜炎并发系统性红斑狼疮：两名接受氟胞嘧啶和两性霉素B治疗的患者
J Clin Pathol. 1977 Mar;30(3):254-61. doi: 10.1136/jcp.30.3.254.
引用本文的文献
1
Fungi under fire: diagnostic capacities and antifungal availability in Peruvian healthcare facilities.真菌面临困境：秘鲁医疗机构的诊断能力与抗真菌药物可及性
Microbiol Spectr. 2025 Aug 5;13(8):e0202024. doi: 10.1128/spectrum.02020-24. Epub 2025 Jun 20.
2
Antifungal Agents' Trends of Utilization, Spending, and Prices in the US Medicaid Programs: 2009-2023.美国医疗补助计划中抗真菌药物的使用、支出及价格趋势：2009 - 2023年
Antibiotics (Basel). 2025 May 16;14(5):518. doi: 10.3390/antibiotics14050518.
3
Is a Fungal Apocalypse Inevitable or Just a Hallucination? An Overview of the Antifungal Armamentarium Used in the Fight against Pathogenic Fungi.真菌末日是不可避免还是只是一场幻觉？用于对抗致病真菌的抗真菌武器库概述。
ACS Med Chem Lett. 2024 Dec 31;16(3):379-387. doi: 10.1021/acsmedchemlett.4c00568. eCollection 2025 Mar 13.
4
Update on invasive fungal infections: emerging trends in the incidence of fungal infections in immunosuppressed patients and associated conditions.侵袭性真菌感染的最新情况：免疫抑制患者真菌感染发病率的新趋势及相关病症
Ther Adv Infect Dis. 2024 Sep 27;11:20499361241282835. doi: 10.1177/20499361241282835. eCollection 2024 Jan-Dec.
5
Multicentric Study on the Clinical Mycology Capacity and Access to Antifungal Treatment in Portugal.葡萄牙的临床真菌学能力和抗真菌治疗可及性的多中心研究。
Mycopathologia. 2024 Jan 24;189(1):15. doi: 10.1007/s11046-024-00830-9.
6
Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections: navigating the frontlines against fungal menaces.揭示匈牙利侵袭性真菌感染的实验室和临床管理能力现状：应对真菌威胁的前沿探索。
Ther Adv Infect Dis. 2023 Dec 18;10:20499361231219315. doi: 10.1177/20499361231219315. eCollection 2023 Jan-Dec.
本文引用的文献
1
Access to flucytosine for the treatment of HIV-associated cryptococcal meningitis in Africa.在非洲获取氟胞嘧啶用于治疗与艾滋病相关的隐球菌性脑膜炎。
Lancet Infect Dis. 2022 Sep;22(9):1262-1264. doi: 10.1016/S1473-3099(22)00315-2. Epub 2022 Jun 21.
2
Outcomes of flucytosine-containing combination treatment for cryptococcal meningitis in a South African national access programme: a cross-sectional observational study.南非国家准入计划中含氟胞嘧啶联合治疗隐球菌性脑膜炎的结局：一项横断面观察性研究。
Lancet Infect Dis. 2022 Sep;22(9):1365-1373. doi: 10.1016/S1473-3099(22)00234-1. Epub 2022 Jun 21.
3
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa.抗真菌药物联合治疗非洲隐球菌性脑膜炎。
N Engl J Med. 2018 Mar 15;378(11):1004-1017. doi: 10.1056/NEJMoa1710922.
4
Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries.隐球菌性脑膜炎：在资源匮乏国家增加基本抗真菌药物的可及性。
Lancet Infect Dis. 2013 Jul;13(7):629-37. doi: 10.1016/S1473-3099(13)70078-1. Epub 2013 Jun 2.
Zotero 插件