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健康志愿者中伦氨西林（KBT-1585）的药代动力学研究。

Pharmacokinetic study of lenampicillin (KBT-1585) in healthy volunteers.

作者信息

Saito A, Nakashima M

出版信息

Antimicrob Agents Chemother. 1986 May;29(5):948-50. doi: 10.1128/AAC.29.5.948.

DOI:10.1128/AAC.29.5.948
PMID:3729355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284190/
Abstract

The pharmacokinetic properties of lenampicillin (KBT-1585), a new ampicillin ester, were investigated in 41 healthy volunteers. The maximum concentration of ampicillin in serum after oral administration of 400 mg of lenampicillin was 6.5 micrograms/ml at 0.70 h, and that after a equimolar dosage of ampicillin was 2.9 micrograms/ml at 0.87 h.

摘要

在41名健康志愿者中研究了新型氨苄西林酯仑氨西林（KBT-1585）的药代动力学特性。口服400mg仑氨西林后，血清中氨苄西林的最大浓度在0.70小时时为6.5微克/毫升，而给予等摩尔剂量的氨苄西林后，在0.87小时时为2.9微克/毫升。

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本文引用的文献

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BRL.8988 (talampicillin), a well-absorbed oral form of ampicillin.BRL.8988（酞氨西林），一种吸收良好的氨苄西林口服剂型。
Antimicrob Agents Chemother. 1974 Jun;5(6):670-1. doi: 10.1128/AAC.5.6.670.
2
The pharmacokinetics of bacampicillin.巴氨西林的药代动力学。
Rev Infect Dis. 1981 Jan-Feb;3(1):110-6. doi: 10.1093/clinids/3.1.110.
3
Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil.食物及胃酸降低对巴卡西林和头孢呋辛酯生物利用度的影响。
Br J Clin Pharmacol. 1984 Oct;18(4):535-9. doi: 10.1111/j.1365-2125.1984.tb02501.x.
4
Bacampicillin: a new orally well-absorbed derivative of ampicillin.巴卡西林：一种新的口服吸收良好的氨苄西林衍生物。
Antimicrob Agents Chemother. 1975 Nov;8(5):518-25. doi: 10.1128/AAC.8.5.518.
5
[Studies on talampicillin. I. Absorption and excretion--comparison with ampicillin and effects of food intake].[酞氨西林的研究。I. 吸收与排泄——与氨苄西林的比较及食物摄入的影响]
Kansenshogaku Zasshi. 1975 Jul;49(11):458-69. doi: 10.11150/kansenshogakuzasshi1970.49.458.
6
Talampicillin: a new derivative of ampicillin.酞氨西林：氨苄西林的一种新衍生物。
Br Med J. 1976 Jun 5;1(6022):1378-80. doi: 10.1136/bmj.1.6022.1378.
7
Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin.巴卡青霉素与氨苄青霉素、匹氨青霉素和阿莫西林的药代动力学比较。
Antimicrob Agents Chemother. 1978 Jan;13(1):90-6. doi: 10.1128/AAC.13.1.90.
8
Bioavailability and metabolism of talampicillin.酞氨苄青霉素的生物利用度与代谢
Chemotherapy. 1978;24(4):217-26. doi: 10.1159/000237784.
9
Influence of food and diet on gastrointestinal drug absorption: a review.食物和饮食对胃肠道药物吸收的影响：综述
J Pharmacokinet Biopharm. 1977 Aug;5(4):291-334. doi: 10.1007/BF01061694.
10
Bioavailability of talampicillin.酞氨苄青霉素的生物利用度。
Br Med J. 1977 Jul 23;2(6081):232-3. doi: 10.1136/bmj.2.6081.232-a.