单次口服仑氨西林后人体血清和混合唾液中氨苄西林的浓度以及血清与混合唾液浓度之间的关系。

Concentrations of ampicillin in human serum and mixed saliva following a single oral administration of lenampicillin, and relationship between serum and mixed saliva concentrations.

作者信息

Akimoto Y, Mochizuki Y, Uda A, Omata H, Shibutani J, Nishimura H, Komiya M, Kaneko K, Kobayashi S, Kuboyama N

机构信息

Second Department of Oral Surgery, Nihon University School of Dentistry, Matsudo, Japan.

出版信息

J Nihon Univ Sch Dent. 1990 Mar;32(1):14-8. doi: 10.2334/josnusd1959.32.14.

DOI:10.2334/josnusd1959.32.14

PMID:2345375

Abstract

The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060 micrograms/ml, respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r = 0.71, P less than 0.001, was found.

摘要

采用纸片法测定单次口服伦氨西林（500毫克）后血清和混合唾液中氨苄西林的浓度。在给药后1、2、3和4小时采集血清和混合唾液样本。血清和混合唾液中氨苄西林的最高浓度出现在伦氨西林给药后1小时，分别为11.55微克/毫升和0.060微克/毫升。发现血清和混合唾液中氨苄西林浓度之间的相关系数显著，r = 0.71，P < 0.001。