Akimoto Y, Mochizuki Y, Uda A, Omata H, Shibutani J, Nishimura H, Komiya M, Kaneko K, Kobayashi S, Kuboyama N
Second Department of Oral Surgery, Nihon University School of Dentistry, Matsudo, Japan.
J Nihon Univ Sch Dent. 1990 Mar;32(1):14-8. doi: 10.2334/josnusd1959.32.14.
The concentrations of ampicillin in serum and mixed saliva after a single oral administration of lenampicillin (500 mg) were determined by the paper disc method. The samples of serum and mixed saliva were obtained at 1, 2, 3 and 4 h after administration. The highest concentrations of ampicillin in serum and mixed saliva occurred 1 h after administration of lenampicillin, and were 11.55 and 0.060 micrograms/ml, respectively. A significant correlation coefficient between the concentrations of ampicillin in serum and mixed saliva, r = 0.71, P less than 0.001, was found.
采用纸片法测定单次口服伦氨西林（500毫克）后血清和混合唾液中氨苄西林的浓度。在给药后1、2、3和4小时采集血清和混合唾液样本。血清和混合唾液中氨苄西林的最高浓度出现在伦氨西林给药后1小时，分别为11.55微克/毫升和0.060微克/毫升。发现血清和混合唾液中氨苄西林浓度之间的相关系数显著，r = 0.71，P < 0.001。
