攻克不可攻克之难题：夸祖鲁 - 纳塔尔省一例对多替拉韦产生耐药性的儿科病例
Breaking the unbreakable: A paediatric case of dolutegravir resistance from KwaZulu-Natal.
作者信息
Malinga Sibongiseni, Khan Aabida, Archary Moherndran
机构信息
Department of Paediatrics, King Edward VIII Hospital, Durban, South Africa.
Department of Virology, Inkosi Albert Luthuli Central Hospital, National Health Laboratory Service (NHLS), Durban, South Africa.
出版信息
South Afr J HIV Med. 2023 May 23;24(1):1458. doi: 10.4102/sajhivmed.v24i1.1458. eCollection 2023.
We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.
我们报告了一例夸祖鲁-纳塔尔省一名13岁男性在开始使用多替拉韦两年后出现多替拉韦耐药的病例。耐药很可能是由于心理社会问题导致依从性差而产生的。该病例凸显了家庭单位在影响依从性以及对转换为基于多替拉韦的治疗方案后出现病毒学失败的有治疗史患者进行密切监测方面所起作用的重要性。
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