严重受损的牙髓感染牙与颈动脉斑块和颈动脉内膜中层厚度异常的相关性：回顾性分析。
Association of severely damaged endodontically infected tooth with carotid plaque and abnormal carotid intima-media thickness: a retrospective analysis.
机构信息
Health Management Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, People's Republic of China.
Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.
出版信息
Clin Oral Investig. 2023 Aug;27(8):4677-4686. doi: 10.1007/s00784-023-05094-z. Epub 2023 Jun 9.
OBJECTIVE
We investigated the association of severely damaged endodontically infected tooth with carotid artery plaque and abnormal mean carotid intima-media thickness (CIMT) ≥ 1.0 mm.
METHODS
A retrospective analysis of 1502 control participants and 1552 participants with severely damaged endodontically infected tooth who received routine medical and dental checkup in Health Management Center, Xiangya Hospital was performed. Carotid plaque and CIMT were measured with B-mode tomographic ultrasound. Data were analyzed using logistic and linear regression.
RESULTS
Severely damaged endodontically infected tooth group had a significantly higher prevalence of carotid plaque (41.62%) compared to 32.22% of carotid plaque in control group. Participants with severely damaged endodontically infected tooth had a significantly higher prevalence of abnormal CIMT (16.17%) and a significantly increased level of CIMT (0.79 ± 0.16 mm) in comparison to 10.79% of abnormal CIMT and 0.77 ± 0.14 mm CIMT in control participants. Severely damaged endodontically infected tooth was significantly related with formation of carotid plaque [1.37(1.18-1.60), P < 0.001], top quartile length [1.21(1.02-1.44), P = 0.029] and top quartile thickness [1.27(1.08-1.51), P = 0.005] of carotid plaque and abnormal CIMT [1.47(1.18-1.83), P < 0.001]. Severely damaged endodontically infected tooth was significantly associated with both single [1.277(1.056-1.546), P = 0.012] and multiple carotid plaques [1.488(1.214-1.825), P < 0.001] and instable carotid plaques [1.380(1.167-1.632), P < 0.001]. Presence of severely damaged endodontically infected tooth increased 0.588 mm of carotid plaque length (P = 0.001), 0.157 mm of carotid plaque thickness (P < 0.001) and 0.015 mm of CIMT (P = 0.005).
CONCLUSION
Severely damaged endodontically infected tooth was associated with carotid plaque and abnormal CIMT.
CLINICAL RELEVANCE
Early treatment of endodontically infected tooth is warranted.
目的
本研究旨在探讨重度牙髓感染患牙与颈动脉斑块和颈动脉内膜中层厚度（CIMT）异常（≥1.0mm）之间的关系。
方法
本研究回顾性分析了 1502 名对照组和 1552 名患有重度牙髓感染患牙的参与者，这些参与者均在湘雅医院健康管理中心接受了常规的医学和牙科检查。采用 B 型断层超声测量颈动脉斑块和 CIMT。使用逻辑和线性回归分析数据。
结果
重度牙髓感染患牙组颈动脉斑块的发生率（41.62%）明显高于对照组（32.22%）。与对照组相比，重度牙髓感染患牙组的 CIMT 异常（16.17%）和 CIMT 水平（0.79±0.16mm）明显升高（10.79%和 0.77±0.14mm）。重度牙髓感染患牙与颈动脉斑块形成显著相关[比值比（OR）为 1.37（1.18-1.60），P<0.001]、颈动脉斑块的最长厚度[OR 为 1.21（1.02-1.44），P=0.029]和颈动脉斑块的最厚厚度[OR 为 1.27（1.08-1.51），P=0.005]。重度牙髓感染患牙与 CIMT 异常[OR 为 1.47（1.18-1.83），P<0.001]、单发颈动脉斑块[OR 为 1.277（1.056-1.546），P=0.012]和多发颈动脉斑块[OR 为 1.488（1.214-1.825），P<0.001]及不稳定颈动脉斑块[OR 为 1.380（1.167-1.632），P<0.001]也显著相关。重度牙髓感染患牙使颈动脉斑块长度增加 0.588mm（P=0.001）、颈动脉斑块厚度增加 0.157mm（P<0.001）和 CIMT 增加 0.015mm（P=0.005）。
结论
重度牙髓感染患牙与颈动脉斑块和 CIMT 异常有关。
临床意义
需要早期治疗牙髓感染患牙。
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