Sakai Y, Sasaki T, Iwamoto S, Koike M
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1249-57.
A prospective study using 10 cases with miscellaneous tumors was performed. Discoid (columnar) tumors were measured three-dimensionally (volume method). Modified criteria for evaluability and for both absolute and relative quantitative sensitivities were employed. The evaluability was 9/10 (90%) and by the volume method true positives (more than PR) were 2/2, true negatives (less than PR) were 9/10 and overall predictive accuracy was 11/12 (92%), and accordance in relative sensitivity ranking (e.g. A drug is better than B drug) was seen in 4/4. However using the original method (mean diameter method) the corresponding figures were 0/0, 9/12, 9/12, (75%) and 2/4, respectively. The utility of this assay in the field of clinical chemotherapy therefore seems very promising.
进行了一项针对10例多种肿瘤患者的前瞻性研究。对盘状（柱状）肿瘤进行三维测量（体积法）。采用了可评估性以及绝对和相对定量敏感性的修改标准。可评估率为9/10（90%），通过体积法，真阳性（大于部分缓解）为2/2，真阴性（小于部分缓解）为9/10，总体预测准确率为11/12（92%），并且在4/4中观察到相对敏感性排名一致（例如一种药物优于另一种药物）。然而，使用原始方法（平均直径法）时，相应的数据分别为0/0、9/12、9/12（75%）和2/4。因此，该检测方法在临床化疗领域的应用前景似乎非常广阔。
