Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
J Nat Prod. 2023 Jun 23;86(6):1385-1391. doi: 10.1021/acs.jnatprod.2c01034. Epub 2023 Jun 9.
Spectasterols A-E (-), aromatic ergosterols with unique ring systems, were isolated from . Compounds and possess a 6/6/6/5/5 ring system with an additional cyclopentene, while and have an uncommon 6/6/6/6 ring system generated by the D-ring expansion via 1,2-alkyl shifts. Compound exhibited cytotoxic activity (IC 6.9 μM) and induced cell cycle arrest and apoptosis in HL60 cells. Compound was anti-inflammatory; it decreased COX-2 levels at the transcription and protein levels and inhibited the nuclear translocation of NF-κB p65.
Spectasterols A-E (-)，具有独特环系的芳基麦角甾醇，从 中分离得到。化合物 和 具有一个额外的环戊烯的 6/6/6/5/5 环系，而 和 则具有通过 D 环扩展经由 1,2-烷基迁移产生的不常见的 6/6/6/6 环系。化合物 表现出细胞毒性活性（IC 6.9 μM），并诱导 HL60 细胞中的细胞周期停滞和细胞凋亡。化合物 具有抗炎作用；它在转录和蛋白水平降低 COX-2 水平，并抑制 NF-κB p65 的核转位。
