Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2), 32 Nguyen Van Linh, Xuanhoa, Phucyen, Vinhphuc, Viet Nam.
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Fitoterapia. 2023 Jul;168:105565. doi: 10.1016/j.fitote.2023.105565. Epub 2023 Jun 7.
Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed that OMT has a wide range of beneficial pharmacological values, consisting of anticancer, antidiabetic, antivirus, and antiinflammtion, as well as the protective activities to the brain, liver, heart, lung, vascular, gastrointestinal, bone, kidney, and skin organs. Various in vitro and in vivo models of pharmacological actions were recorded in regard to the usage of alkaloidal OMT. Mechanisms underlying anticancer activity of this compound may have been possibly involved anti-proliferation, invasion, migration, angiogenesis, epithelial-mesenchymal transition of cells, autophagy, especially apoptotic cell deaths. OMT could reduce hyperglycemia and hyperlipemia in a high-fat diet and streptozotocin-stimulated diabetic mice by improving insulin secretion and sensitivity. OMT suppressed gastric ulcer via gastric inflammatory and oxidative inhibitions, and pro-apoptotic actions. It turns out that OMT is relatively safe for cell and animal experiments. In this study, we offer a systematic review of natural occurrence, pharmacological potentials, possible mechanisms of action, pharmacokinetics, and bioavailability. Clinical research with OMT is needed to extensively elucidate its health potential benefits.
氧化苦参碱（OMT）是一种喹诺里西啶生物碱，是从苦参属植物中提取的主要苦参型生物碱之一。生长研究表明，OMT 具有广泛的有益的药理作用，包括抗癌、抗糖尿病、抗病毒和抗炎，以及对大脑、肝脏、心脏、肺、血管、胃肠道、骨骼、肾脏和皮肤器官的保护作用。已经记录了关于生物碱 OMT 使用的各种体外和体内药理学作用模型。这种化合物的抗癌活性的机制可能涉及抗增殖、侵袭、迁移、血管生成、细胞上皮-间充质转化、自噬，特别是细胞凋亡。OMT 通过改善胰岛素分泌和敏感性，可降低高脂肪饮食和链脲佐菌素诱导的糖尿病小鼠的高血糖和高脂血症。OMT 通过抑制胃炎症和氧化反应以及促进凋亡作用来抑制胃溃疡。事实证明，OMT 对细胞和动物实验相对安全。在这项研究中，我们系统地综述了其天然存在、药理学潜力、可能的作用机制、药代动力学和生物利用度。需要进行 OMT 的临床研究来广泛阐明其健康潜在益处。
