Junqueira L C, Montes G S, Toledo O M, Joazeiro P P
Ann Trop Med Parasitol. 1986 Feb;80(1):27-41. doi: 10.1080/00034983.1986.11811981.
The connective tissue matrix of hepatic granulomas from Swiss mice, each infected with 20 Schistosoma mansoni cercariae, was examined using morphological, histochemical and biochemical methods, during the evolution of the disease. Evidence was obtained by both light and electron microscopy that suggested the presence of two different collagen populations which appeared successively during granuloma evolution. Morphological features suggesting the occurrence of collagenolysis were observed at the final stage of granuloma development. The connective tissue matrix of schistosome granulomas was devoid of elastic system fibres. Schistosome egg granulomas contain dermatan sulphate-proteoglycan.
对每只感染20条曼氏血吸虫尾蚴的瑞士小鼠肝脏肉芽肿的结缔组织基质，在疾病发展过程中采用形态学、组织化学和生物化学方法进行了检查。通过光学显微镜和电子显微镜均获得了证据，表明存在两种不同的胶原蛋白群体，它们在肉芽肿演变过程中相继出现。在肉芽肿发展的最后阶段观察到了提示胶原溶解发生的形态学特征。血吸虫肉芽肿的结缔组织基质缺乏弹性系统纤维。血吸虫卵肉芽肿含有硫酸皮肤素蛋白聚糖。
