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[麻醉后护理单元转运期间术后低氧血症的危险因素及转运监测的影响:一项回顾性倾向评分匹配数据库分析]

[Risk factors for postoperative hypoxemia during transport to the postanesthesia care unit and influence of transport monitoring : A retrospective propensity score-matched databank analysis].

作者信息

Haller Katharina, Trauzeddel Ralf Felix, Treskatsch Sascha, Berger Christian

机构信息

Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität and Humboldt Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Deutschland.

出版信息

Anaesthesiologie. 2023 Jul;72(7):488-497. doi: 10.1007/s00101-023-01296-y. Epub 2023 Jun 9.

DOI:10.1007/s00101-023-01296-y
PMID:37296345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10322755/
Abstract

BACKGROUND

Within a central operating room area, after general anesthesia (GA) patients are at risk of hypoxemia during transport to the postanesthesia care unit (PACU); however, specific risk factors have not been conclusively clarified and uniform recommendations for monitoring vital signs during transport within a central operating room area complex do not exist. The purpose of this retrospective database analysis was to identify risk factors for hypoxemia during this transport and to determine whether the use of transport monitoring (TM) affects the initial value of peripheral venous oxygen saturation (SO) in the PACU.

MATERIAL AND METHODS

This analysis was performed on a retrospectively extracted dataset of procedures in GA within a central operating room area of a tertiary care hospital from 2015 to 2020. The emergence from GA was conducted in the operating room with subsequent transport to the PACU. The transport distance was between 31 and 72 m. Risk factors for initial hypoxemia in the PACU, defined as peripheral oxygen saturation (SO) below 90%, were determined using multivariate analysis. After splitting the dataset into patients without TM (group OM) and with TM (group MM) and propensity score matching, the influence of TM on initial SO and the Aldrete score after arrival in the PACU were examined.

RESULTS AND DISCUSSION

From a total of 22,638 complete datasets included in the analysis, 8 risk factors for initial hypoxemia in PACU were identified: age > 65 years, body mass index (BMI) > 30 kg/m, chronic obstructive pulmonary disease (COPD), intraoperative airway driving pressure (∆p) > 15 mbar and positive endexpiratory pressure (PEEP) > 5 mbar, intraoperative administration of a long-acting opioids, first preoperative SO < 97%, and last SO < 97% measured after emergence from anesthesia before transport. At least 1 risk factor for postoperative hypoxemia was present in 90% of all patients. After propensity score matching, 3362 datasets per group remained for analysis of the influence of TM. Patients transported with TM revealed a higher SO at PACU arrival (MM 97% [94; 99%], OM 96% [94; 99%], p < 0.001). In a subgroup analysis, this difference between groups remained in the presence of one or more risk factors (MM 97% [94; 99%], OM 96% [94; 98%], p < 0.001, n = 6044) but was not detectable in the absence of risk factors for hypoxemia (MM 97% [97; 100%], OM 99% [97; 100%], p < 0.393, n = 680). Furthermore, the goal of an Aldrete score > 8 at PACU arrival was achieved significantly more often in monitored patients (MM 2830 [83%], OM: 2665 [81%], p = 0.004). Critical hypoxemia (SO < 90%) at PACU arrival had an overall low occurrence within propensity matched datasets and showed no difference between groups (MM: 161 [5%], OM 150 [5%], p = 0.755). According to these results, consistent use of TM leads to a higher SO and Aldrete score at PACU arrival, even after a short transport distance within an operating room area. Consequently, it appears to be reasonable to avoid unmonitored transport after general anesthesia, even for short distances.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/8312db16000e/101_2023_1296_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/e3dea0f12bd6/101_2023_1296_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/9540a41de5fc/101_2023_1296_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/8312db16000e/101_2023_1296_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/e3dea0f12bd6/101_2023_1296_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/9540a41de5fc/101_2023_1296_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b73/10322755/8312db16000e/101_2023_1296_Fig3_HTML.jpg
摘要

背景

在中心手术室区域内,全身麻醉(GA)后患者在转运至麻醉后护理单元(PACU)的过程中存在低氧血症风险;然而,具体的风险因素尚未得到最终明确,且对于在中心手术室区域复杂环境中转运期间监测生命体征也不存在统一的建议。这项回顾性数据库分析的目的是确定转运期间低氧血症的风险因素,并确定使用转运监测(TM)是否会影响PACU中外周静脉血氧饱和度(SO)的初始值。

材料与方法

本分析是基于对一家三级护理医院2015年至2020年中心手术室区域内GA手术的回顾性提取数据集进行的。全身麻醉苏醒在手术室进行,随后转运至PACU。转运距离在31至72米之间。使用多变量分析确定PACU中初始低氧血症的风险因素,定义为外周血氧饱和度(SO)低于90%。在将数据集分为未使用TM的患者组(OM组)和使用TM的患者组(MM组)并进行倾向得分匹配后,研究了TM对初始SO以及到达PACU后的Aldrete评分的影响。

结果与讨论

在分析纳入的总共22638个完整数据集中,确定了PACU中初始低氧血症的8个风险因素:年龄>65岁、体重指数(BMI)>30kg/m²、慢性阻塞性肺疾病(COPD)、术中气道驱动压(∆p)>15mbar以及呼气末正压(PEEP)>5mbar、术中使用长效阿片类药物、术前首次SO<97%以及麻醉苏醒后转运前最后一次SO<97%。所有患者中有90%至少存在1个术后低氧血症风险因素。经过倾向得分匹配后,每组保留3362个数据集用于分析TM的影响。使用TM转运的患者在到达PACU时显示出更高的SO(MM组97%[94;99%],OM组96%[94;99%],p<0.001)。在亚组分析中,在存在一个或多个风险因素的情况下,两组之间的这种差异仍然存在(MM组97%[94;99%],OM组96%[94;98%],p<0.001,n=6044),但在不存在低氧血症风险因素的情况下无法检测到(MM组97%[97;100%],OM组99%[97;100%],p<0.393,n=680)。此外,在监测患者中,到达PACU时Aldrete评分>8的目标实现频率显著更高(MM组2830例[83%],OM组:2665例[81%],p=0.004)。在倾向得分匹配的数据集中,到达PACU时严重低氧血症(SO<90%)的总体发生率较低,且两组之间无差异(MM组:161例[5%],OM组150例[5%],p=0.755)。根据这些结果,即使在手术室区域内转运距离较短,持续使用TM也会使到达PACU时的SO和Aldrete评分更高。因此,即使距离较短,全身麻醉后避免无监测的转运似乎是合理的。

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