探戈阿根廷疗法对乳腺癌幸存者癌症相关疲劳及生活质量的疗效：一项随机对照试验

Efficacy of Tango Argentino for Cancer-Associated Fatigue and Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial.

作者信息

Schad Friedemann, Rieser Thomas, Becker Sarah, Groß Jessica, Matthes Harald, Oei Shiao Li, Thronicke Anja

机构信息

Research Institute Havelhöhe, Hospital Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany.

Interdisciplinary Oncology and Palliative Care, Hospital Gemeinschaftskrankenhaus Havelhöhe, 14089 Berlin, Germany.

出版信息

Cancers (Basel). 2023 May 26;15(11):2920. doi: 10.3390/cancers15112920.

DOI:10.3390/cancers15112920

PMID:37296883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10251919/

Abstract

BACKGROUND

Persistent impairments of quality of life-in particular, cancer-associated fatigue-are a major limitation for breast cancer survivors. As physical activity and mindfulness interventions have been shown to be effective in reducing fatigue symptoms, we investigated the efficacy of a six-week Argentine tango program.

METHODS

A randomized controlled trial was conducted with 60 breast cancer survivors diagnosed with stage I-III tumors 12-48 months prior to study enrollment and who had increased symptoms of fatigue. The participants were randomly assigned with a 1:1 allocation to either the tango or the waiting group. The treatment consisted of six weeks of supervised weekly one-hour tango group-sessions. Self-reported fatigue and further quality of life parameters were assessed at baseline and six weeks post-baseline. Longitudinal changes, correlations, Cohen's D () effect sizes, and association factors were also calculated.

RESULTS

Superiority of the tango intervention over the waiting list control was found in terms of improvement in fatigue ( = -0.64; 95%CI, -1.2 to -0.08; = 0.03), especially cognitive fatigue. In addition, a superiority of the tango intervention over the waiting list was found in the improvement of diarrhea ( = -0.69; 95%CI, -1.25 to -0.13; = 0.02). A pooled pre-post analysis of the 50 participants completing the six-week tango program revealed a close to 10% improvement of fatigue ( = 0.0003), insomnia ( = 0.008) and further quality of life outcomes. Adjusted multivariate linear regression analyses revealed the greatest improvements for participants who were more active in sports. In particular, survivors who received endocrine therapies, were obese, or had no prior dance experience seemed to especially benefit from the tango program.

CONCLUSIONS

This randomized controlled trial demonstrated that a six-week Argentine tango program improves fatigue in breast cancer survivors. Further trials are warranted to determine whether such improvements lead to better long-term clinical outcomes.

TRIAL REGISTRATION

trial registration number DRKS00021601. Retrospectively registered on 21 August 2020.

摘要

背景

生活质量的持续受损，尤其是癌症相关疲劳，是乳腺癌幸存者的主要限制因素。由于体育活动和正念干预已被证明可有效减轻疲劳症状，我们研究了为期六周的阿根廷探戈课程的效果。

方法

对60名乳腺癌幸存者进行了一项随机对照试验，这些幸存者在研究入组前12 - 48个月被诊断为I - III期肿瘤，且疲劳症状有所加重。参与者以1:1的比例随机分配到探戈组或等待组。治疗包括为期六周、每周一次、每次一小时的有监督的探戈小组课程。在基线和基线后六周评估自我报告的疲劳及其他生活质量参数。还计算了纵向变化、相关性、科恩d效应量和关联因素。

结果

在疲劳改善方面（d = -0.64；95%置信区间，-1.2至-0.08；P = 0.03），尤其是认知疲劳方面，发现探戈干预优于等待名单对照。此外，在腹泻改善方面（d = -0.69；95%置信区间，-1.25至-0.13；P = 0.02），发现探戈干预优于等待名单。对完成六周探戈课程的50名参与者进行的汇总前后分析显示，疲劳（P = 0.0003）、失眠（P = 0.008）及其他生活质量结果有近10%的改善。调整后的多变量线性回归分析显示体育活动更积极的参与者改善最大。特别是接受内分泌治疗、肥胖或以前没有舞蹈经验的幸存者似乎尤其从探戈课程中受益。