Haggstrom Lucy R, Vardy Janette L, Carson Emma-Kate, Segara Davendra, Lim Elgene, Kiely Belinda E
Campbelltown Hospital, Therry Road, Campbelltown, NSW 2560, Australia.
Faculty of Medicine and Health, University of Sydney, Camperdown, NSW 2006, Australia.
Cancers (Basel). 2022 Feb 12;14(4):920. doi: 10.3390/cancers14040920.
Endocrine therapy forms the backbone of systemic therapy for the majority of persons with early and late-stage breast cancer. However, the side effects can negatively affect quality of life, and impact treatment adherence and overall oncological outcomes. Adverse effects on cognition are common, underreported and challenging to manage. We aim to describe the nature, incidence, risk factors and underlying mechanisms of endocrine therapy-induced cognitive dysfunction. We conducted a comprehensive literature review of the studies reporting on cognitive dysfunction associated with endocrine therapies for breast cancer. We also summarise prevention and treatment strategies, and ongoing research. Given that patients are taking endocrine therapies for longer durations than ever before, it is essential that these side effects are managed pro-actively within a multi-disciplinary team in order to promote adherence to endocrine therapy and improve patients' quality of life.
内分泌治疗是大多数早期和晚期乳腺癌患者全身治疗的核心。然而，其副作用会对生活质量产生负面影响，并影响治疗依从性和整体肿瘤治疗效果。对认知的不良影响很常见，报告不足且难以处理。我们旨在描述内分泌治疗引起的认知功能障碍的性质、发生率、风险因素和潜在机制。我们对报告乳腺癌内分泌治疗相关认知功能障碍的研究进行了全面的文献综述。我们还总结了预防和治疗策略以及正在进行的研究。鉴于患者接受内分泌治疗的时间比以往任何时候都更长，必须在多学科团队中积极管理这些副作用，以促进对内分泌治疗的依从性并提高患者的生活质量。
