Sandel M E, Abrams P L, Horn L J
Arch Phys Med Rehabil. 1986 Jul;67(7):469-72.
Hypertension after brain injury requires comprehensive evaluation and management. Focal brain injury to centers of blood pressure regulation, high levels of circulating catecholamines from generalized trauma or intracranial lesions, increased intracranial pressure, pheochromocytomas unmasked after trauma, and occult spinal cord injury with hyperreflexia represent possible causes of hypertension after brain injury. This case of a brain-injured patient who had episodes of hypertension and diaphoresis with catecholamine elevations in plasma and urine, and evidence of hypothalamic-pituitary dysfunction, demonstrates the importance of a thorough neuroendocrine evaluation in brain-injured patients with hypertension. When high levels of catecholamines are found, without further evidence of a pheochromocytoma, treatment with a beta blocker is appropriate.
脑损伤后高血压需要进行全面评估和管理。血压调节中枢的局灶性脑损伤、全身性创伤或颅内病变导致的循环儿茶酚胺水平升高、颅内压升高、创伤后隐匿的嗜铬细胞瘤以及伴有反射亢进的隐匿性脊髓损伤均可能是脑损伤后高血压的病因。该例脑损伤患者出现高血压发作、多汗,血浆和尿液中儿茶酚胺升高,并有下丘脑-垂体功能障碍的证据,这表明对脑损伤后高血压患者进行全面神经内分泌评估的重要性。当发现儿茶酚胺水平升高而无嗜铬细胞瘤的进一步证据时,使用β受体阻滞剂进行治疗是合适的。