Feldmann E, Bromfield E, Navia B, Pasternak G W, Posner J B
Arch Neurol. 1986 Jul;43(7):714-8. doi: 10.1001/archneur.1986.00520070070021.
A 68-year-old woman presented with an 18-month history of low back pain followed by leg weakness, dementia, and incontinence. Myelography revealed an intradural, extramedullary block from L-2 to L-4, and cranial computed tomography demonstrated ventriculomegaly. Excision of a benign schwannoma resulted in rapid relief of back pain and more gradual normalization of mental function and hydrocephalus. Five similar cases of dementia and hydrocephalus complicating spinal cord tumor have been reported. A variety of mechanisms have been proposed to explain the association but the pathophysiology is still unclear. Spinal tumor should be considered in the differential diagnosis of dementia and of communicating hydrocephalus.
一名68岁女性,有18个月的下背痛病史,随后出现腿部无力、痴呆和尿失禁。脊髓造影显示L-2至L-4节段硬膜内、髓外阻滞,头颅计算机断层扫描显示脑室扩大。切除良性神经鞘瘤后,背痛迅速缓解,精神功能和脑积水逐渐恢复正常。已有5例脊髓肿瘤并发痴呆和脑积水的类似病例报道。人们提出了多种机制来解释这种关联,但病理生理学仍不清楚。在痴呆和交通性脑积水的鉴别诊断中应考虑脊髓肿瘤。