UMR CNRS 7021, Laboratory Bioimaging and Pathologies, Tumoral Signaling and Therapeutic Targets, Faculty of Pharmacy, University of Strasbourg, 67405 lllkirch, France.
Laboratory of Biochemistry and Molecular Biology, Department of Cancer Molecular Genetics, University Hospital of Strasbourg, 67200 Strasbourg, France.
Int J Mol Sci. 2023 May 23;24(11):9137. doi: 10.3390/ijms24119137.
Tumor metabolism is emerging as a potential target for cancer therapies. This new approach holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is resistant to conventional treatments, for which improving therapeutic strategies is a major challenge. The presence of glioma stem cells is a critical factor in therapy resistance, thus making it essential to eliminate these cells for the long-term survival of cancer patients. Recent advancements in our understanding of cancer metabolism have shown that glioblastoma metabolism is highly heterogeneous, and that cancer stem cells exhibit specific metabolic traits that support their unique functionality. The objective of this review is to examine the metabolic changes in glioblastoma and investigate the role of specific metabolic processes in tumorigenesis, as well as associated therapeutic approaches, with a particular focus on glioma stem cell populations.
肿瘤代谢正在成为癌症治疗的一个潜在靶点。这种新方法对胶质母细胞瘤的治疗特别有希望，胶质母细胞瘤是一种高度致命的脑肿瘤，对传统治疗方法具有耐药性，因此，改进治疗策略是一个主要挑战。胶质瘤干细胞的存在是治疗耐药性的一个关键因素，因此，为了癌症患者的长期生存，必须消除这些细胞。最近对癌症代谢的认识进展表明，胶质母细胞瘤代谢具有高度异质性，并且癌症干细胞表现出特定的代谢特征，这些特征支持其独特的功能。本综述的目的是检查胶质母细胞瘤中的代谢变化，并研究特定代谢过程在肿瘤发生中的作用，以及相关的治疗方法，特别关注胶质瘤干细胞群体。
