Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Centre, University of Granada, 18016 Armilla, Spain.
Sport and Health Research Centre, University of Granada, C/Menéndez Pelayo 32, 18016 Granada, Spain.
Int J Mol Sci. 2023 May 27;24(11):9367. doi: 10.3390/ijms24119367.
Vanadium (V) is a trace mineral whose biological activity, role as a micronutrient, and pharmacotherapeutic applications remain unknown. Over the last years, interest in V has increased due to its potential use as an antidiabetic agent mediated by its ability to improve glycemic metabolism. However, some toxicological aspects limit its potential therapeutic application. The present study aims to evaluate the effect of the co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) as a possible strategy to reduce the toxicity of BMOV. Treating hepatic cells with BMOV reduced cell viability under the present conditions, but cell viability was corrected when cells were co-incubated with BMOV and Cu. Additionally, the effect of these two minerals on nuclear and mitochondrial DNA was evaluated. Co-treatment with both metals reduced the nuclear damage caused by BMOV. Moreover, treatment with these two metals simultaneously tended to reduce the ND1/ND4 deletion of the mitochondrial DNA produced with the treatment using BMOV alone. In conclusion, these results showed that combining Cu and V could effectively reduce the toxicity associated with V and enhance its potential therapeutic applications.
钒（V）是一种微量元素，其生物活性、作为必需微量元素的作用和药物治疗应用仍然未知。近年来，由于其改善血糖代谢的能力，钒作为一种抗糖尿病药物的潜在用途引起了人们的兴趣。然而，一些毒理学方面的问题限制了其潜在的治疗应用。本研究旨在评估铜（Cu）和双（麦芽酚）氧钒（IV）（BMOV）共同处理作为降低 BMOV 毒性的一种可能策略的效果。在目前的条件下，用 BMOV 处理肝细胞会降低细胞活力，但当细胞与 BMOV 和 Cu 共孵育时，细胞活力得到纠正。此外，还评估了这两种矿物质对核和线粒体 DNA 的影响。两种金属的共同处理减少了 BMOV 引起的核损伤。此外，同时用这两种金属处理可减少单独用 BMOV 处理产生的线粒体 DNA 的 ND1/ND4 缺失。总之，这些结果表明，联合使用铜和钒可以有效地降低与钒相关的毒性，并增强其潜在的治疗应用。
