Biomedical Research Centre (CIBM), Sport and Health Research Centre (IMUDs), Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, E-18071 Granada, Spain.
CIBERehd, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Department of Pharmacology, CIBM, University of Granada, E-18071 Granada, Spain.
Nutrients. 2021 Apr 11;13(4):1256. doi: 10.3390/nu13041256.
Diabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.
糖尿病是一种具有炎症成分的疾病，伴随着贫血状态。钒（V）是一种通过刺激胰岛素信号起作用的抗糖尿病药物。铁调素可阻止铁的肠道吸收和铁从其沉积物中的释放。我们旨在研究 V 对肝源性铁调素 mRNA 表达的影响及其对链脲佐菌素诱导的糖尿病 Wistar 大鼠血液学参数的影响。检查了五周的对照健康大鼠、糖尿病大鼠和每天用 1 毫克 V 治疗的糖尿病大鼠。在饮食和血清样本中测量矿物质水平。在肝组织样本中定量测定铁调素的表达。在血清或全血样本中测定炎症和血液学参数。糖尿病大鼠的炎症状态高于对照组，而糖尿病大鼠的血液学参数低于对照组。与对照组和未治疗的糖尿病组相比，用 V 治疗的糖尿病大鼠的肝源性铁调素 mRNA 表达显著降低。炎症状态与未治疗的糖尿病组相似。然而，在 V 治疗后，血液学特征得到改善，达到与对照组相似的水平。与未治疗的糖尿病大鼠相比，用 V 治疗的大鼠血清铁水平升高。我们得出结论，V 可降低糖尿病大鼠肝源性铁调素的基因表达，改善糖尿病引起的贫血状态。
