Department of BioNano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Swsonaki Inc., Gwangyang Frontier-Valley 3rd, 30 Gaseok-ro, Incheon 22827, Republic of Korea.
Int J Mol Sci. 2023 Jun 2;24(11):9669. doi: 10.3390/ijms24119669.
Acne is a common skin condition caused by the growth of certain bacteria. Many plant extracts have been investigated for their potential to combat acne-inducing microbes, and one such plant extract is microwave-assisted extract (MA-OHE). The MA-OHE was loaded onto zinc-aminoclay (ZnAC) and encapsulated in a Pickering emulsion system (MA-OHE/ZnAC PE) to evaluate its therapeutic potential against acne-inducing microbes. Dynamic light scattering and scanning electron microscopy were used to characterize MA-OHE/ZnAC PE with a mean particle diameter of 353.97 nm and a PDI of 0.629. The antimicrobial effect of MA-OHE/ZnAC was evaluated against () and (), which contribute to acne inflammation. The antibacterial activity of MA-OHE/ZnAC was 0.1 and 0.025 mg/mL to and , respectively, which were close to naturally derived antibiotics. Additionally, the cytotoxicity of MA-OHE, ZnAC, and MA-OHE/ZnAC was tested, and the results showed that they had no cytotoxic effects on cultured human keratinocytes in a range of 10-100 μg/mL. Thus, MA-OHE/ZnAC is suggested to be a promising antimicrobial agent for treating acne-inducing microbes, while MA-OHE/ZnAC PE is a potentially advantageous dermal delivery system.
痤疮是一种常见的皮肤病症，由某些细菌的生长引起。许多植物提取物因其对抗诱发痤疮的微生物的潜力而受到研究，其中一种植物提取物是微波辅助提取（MA-OHE）。MA-OHE 被负载到锌-氨基粘土（ZnAC）上，并封装在 Pickering 乳液体系（MA-OHE/ZnAC PE）中，以评估其针对诱发痤疮的微生物的治疗潜力。动态光散射和扫描电子显微镜用于表征 MA-OHE/ZnAC PE，其平均粒径为 353.97nm，PDI 为 0.629。MA-OHE/ZnAC 对 （）和 （）的抗菌作用进行了评估，这两种细菌都有助于痤疮炎症。MA-OHE/ZnAC 的抗菌活性对 和 分别为 0.1 和 0.025mg/mL，接近天然来源的抗生素。此外，还测试了 MA-OHE、ZnAC 和 MA-OHE/ZnAC 的细胞毒性，结果表明它们在 10-100μg/mL 的范围内对培养的人角质形成细胞没有细胞毒性作用。因此，MA-OHE/ZnAC 被认为是一种有前途的治疗诱发痤疮的微生物的抗菌剂，而 MA-OHE/ZnAC PE 是一种有潜力的皮肤递药系统。
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