Institut Galien Paris-Sud, CNRS UMR 8612, Univ Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 5 rue J.B. Clément, 92296 Châtenay-Malabry, France.
Institut Galien Paris-Sud, CNRS UMR 8612, Univ Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, 5 rue J.B. Clément, 92296 Châtenay-Malabry, France.
J Control Release. 2019 Sep 10;309:302-332. doi: 10.1016/j.jconrel.2019.07.003. Epub 2019 Jul 8.
An increased interest in Pickering emulsions has emerged over the last 15 years, mainly related to their very attractive properties compared to regular emulsions, namely their excellent stability and their numerous possible applications. In this review, after detailing the interest of Pickering emulsions, their main preparation processes are presented and their advantages and disadvantages discussed. In the third part, the key parameters that govern Pickering emulsions type, droplet size and stability are analyzed. Finally, the interest and the potential of Pickering emulsions for pharmaceutical applications are exposed and discussed, taking all the administration routes into consideration and focusing on organic particles.
在过去的 15 年中，人们对 Pickering 乳液的兴趣日益浓厚，这主要与它们与常规乳液相比具有非常有吸引力的特性有关，即它们具有极好的稳定性和众多可能的应用。在本综述中，在详细说明了 Pickering 乳液的兴趣之后，介绍了它们的主要制备工艺，并讨论了它们的优缺点。在第三部分中，分析了控制 Pickering 乳液类型、液滴大小和稳定性的关键参数。最后，探讨并讨论了 Pickering 乳液在药物应用中的兴趣和潜力，同时考虑了所有的给药途径，并重点关注有机颗粒。
