Department of BioNano Technology, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, Republic of Korea.
Department of Beauty Design Management, Hansung University, 116 Samseongyoro-16 gil, Seoul, 02876, Republic of Korea.
Sci Rep. 2021 Sep 8;11(1):17821. doi: 10.1038/s41598-021-97363-8.
The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity, moisturizing effect, and clinical skin irritation of the hand gel are evaluated. The hand gel with 0.5 wt.% ZnAC and 1.0 v/v% O. humifusa extract can kill more than 99% Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria) after 24 h. Toxicity evaluation shows that, the hand gel does not affect the viability of mammalian HaCaT cells. Additionally, skin moisture is increased by applying the hand gel while its viscosity is at the standard level of commercial products. The hand gel has a skin irritation index of 0.0 and is classified as a non-irritating product. We successfully formulated hand gel from ZnAC, glucomannan, glycerol, and O. humifusa extract. Owing to the high antimicrobial activity and skin protection of hand gels, they are suitable to be used as hand sanitizers in restaurants, hospitals, and homes effectively.
我们之前的报告声称锌-氨基粘土（ZnAC）具有高抗菌能力和低毒性。在这项研究中，我们基于 ZnAC 和仙人掌（Opuntia humifusa）提取物（一种高保湿剂）配制了一种新型手部凝胶。评估了手部凝胶的抗菌活性、细胞毒性、保湿效果和临床皮肤刺激性。含有 0.5wt.% ZnAC 和 1.0v/v%仙人掌提取物的手部凝胶在 24 小时后可杀死超过 99%的大肠杆菌（革兰氏阴性菌）和金黄色葡萄球菌（革兰氏阳性菌）。毒性评估表明，手部凝胶不会影响哺乳动物 HaCaT 细胞的活力。此外，涂抹手部凝胶后皮肤水分增加，而其粘度处于商业产品的标准水平。手部凝胶的皮肤刺激性指数为 0.0，被归类为非刺激性产品。我们成功地从 ZnAC、葡甘露聚糖、甘油和仙人掌提取物中配制了手部凝胶。由于手部凝胶具有高抗菌活性和皮肤保护作用，它们适合在餐厅、医院和家庭中用作有效的手部消毒剂。
