State Key Laboratory of Chemical Oncogenomics, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Open FIESTA Center, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Int J Mol Sci. 2023 Jun 2;24(11):9686. doi: 10.3390/ijms24119686.
Neurodegenerative diseases (NDDs) have become a significant global public health problem and a major societal burden. The World Health Organization predicts that NDDs will overtake cancer as the second most common cause of human mortality within 20 years. Thus, it is urgently important to identify pathogenic and diagnostic molecular markers related to neurodegenerative processes. Autophagy is a powerful process for removing aggregate-prone proteins in neurons; defects in autophagy are often associated with the pathogenesis of NDDs. Long non-coding RNAs (lncRNAs) have been suggested as key regulators in neurodevelopment; aberrant regulation of lncRNAs contributes to neurological disorders. In this review, we summarize the recent progress in the study of lncRNAs and autophagy in the context of neurodegenerative disorders, especially Alzheimer's disease (AD) and Parkinson's disease (PD). The information presented here should provide guidance for future in-depth investigations of neurodegenerative processes and related diagnostic molecular markers and treatment targets.
神经退行性疾病（NDDs）已成为全球重大公共卫生问题和主要社会负担。世界卫生组织预计，在 20 年内，NDDs 将超过癌症，成为人类第二大致死原因。因此，迫切需要确定与神经退行性过程相关的致病和诊断分子标志物。自噬是一种清除神经元中易于聚集的蛋白质的强大过程；自噬缺陷常与 NDD 的发病机制有关。长非编码 RNA（lncRNA）被认为是神经发育的关键调节因子；lncRNA 的异常调节导致神经紊乱。在这篇综述中，我们总结了 lncRNA 和自噬在神经退行性疾病（尤其是阿尔茨海默病（AD）和帕金森病（PD））背景下的研究进展。这里提供的信息应该为深入研究神经退行性过程以及相关的诊断分子标志物和治疗靶点提供指导。
