靶向神经退行性疾病中的自噬：从分子机制到临床治疗。
Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics.
机构信息
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Clin Exp Pharmacol Physiol. 2021 Jul;48(7):943-953. doi: 10.1111/1440-1681.13500. Epub 2021 Apr 21.
Abstract
Many neurodegenerative diseases are associated with pathological aggregation of proteins in neurons. Autophagy is a natural self-cannibalization process that can act as a powerful mechanism to remove aged and damaged organelles as well as protein aggregates. It has been shown that promoting autophagy can attenuate or delay neurodegeneration by removing protein aggregates. In this paper, we will review the role of autophagy in Alzheimer's disease (AD), Parkinson's Disease (PD), and Huntington's Disease (HD) and discuss opportunities and challenges of targeting autophagy as a potential therapeutic avenue for treatment of these common neurodegenerative diseases.
摘要
许多神经退行性疾病都与神经元中蛋白质的病理性聚集有关。自噬是一种自然的自我吞噬过程，可以作为一种强大的机制来清除衰老和受损的细胞器以及蛋白质聚集体。已经表明，通过去除蛋白质聚集体，促进自噬可以减轻或延迟神经退行性变。本文将综述自噬在阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）中的作用，并讨论将自噬作为这些常见神经退行性疾病治疗的潜在治疗靶点的机会和挑战。
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