Kamisah Yusof, Jalil Juriyati, Yunos Nurhanan Murni, Zainalabidin Satirah
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Centre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
Plants (Basel). 2023 May 24;12(11):2096. doi: 10.3390/plants12112096.
Cardiac diseases, such as myocardial infarction and heart failure, have become a major clinical problem globally. The accumulating data demonstrate that bioactive compounds with antioxidant and anti-inflammatory properties have favorable effects on clinical problems. Kaempferol is a flavonoid found in various plants; it has demonstrated cardioprotective properties in numerous cardiac injury models. This review aims to collate updated information regarding the effects of kaempferol on cardiac injury. Kaempferol improves cardiac function by alleviating myocardial apoptosis, fibrosis, oxidative stress, and inflammation while preserving mitochondrial function and calcium homeostasis. However, the mechanisms of action of its cardioprotective properties remain unclear; therefore, elucidating its action could provide insight into directions for future studies.
心脏病，如心肌梗死和心力衰竭，已成为全球主要的临床问题。越来越多的数据表明，具有抗氧化和抗炎特性的生物活性化合物对临床问题具有有益作用。山奈酚是一种存在于多种植物中的黄酮类化合物；它在众多心脏损伤模型中已显示出心脏保护特性。本综述旨在整理有关山奈酚对心脏损伤影响的最新信息。山奈酚通过减轻心肌细胞凋亡、纤维化、氧化应激和炎症，同时维持线粒体功能和钙稳态来改善心脏功能。然而，其心脏保护特性的作用机制仍不清楚；因此，阐明其作用可为未来研究方向提供见解。
