Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Read-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra (Szczecińska), Poland.
Nutrients. 2023 Jun 2;15(11):2611. doi: 10.3390/nu15112611.
In a prospective study, we measured the associations between three serum elements (Se, Zn and Cu) and the prognosis of 1475 patients with four different types of cancer (breast, prostate, lung and larynx) from University Hospitals in Szczecin, Poland. The elements were measured in serum taken after diagnosis and prior to treatment. Patients were followed from the date of diagnosis until death from any cause or until the last follow-up date (mean years of follow-up: 6.0-9.8 years, according to site). Kaplan-Meier curves were constructed for all cancers combined and for each cancer separately. Age-adjusted hazard ratios (HRs) were estimated using Cox regression. The outcome was all-cause mortality. A Se level in the highest quartile was also associated with a reduced mortality (HR = 0.66; 95%CI 0.49-0.88; = 0.005) in all-cause mortality for all cancers combined. Zn level in the highest quartile was also associated with reduced mortality (HR = 0.55; 95%CI 0.41-0.75; = 0.0001). In contrast, a Cu level in the highest quartile was associated with an increase in mortality (HR = 1.91; 95%CI 1.56-2.08; = 0.0001). Three serum elements-selenium, zinc and copper-are associated with the prognosis of different types of cancer.
在一项前瞻性研究中，我们测量了三种血清元素（硒、锌和铜）与来自波兰什切青大学医院的 1475 名患有四种不同类型癌症（乳腺癌、前列腺癌、肺癌和喉癌）的患者预后之间的关系。在诊断后治疗前采集血清样本测量元素。从诊断之日起，对患者进行随访，直至任何原因死亡或直至最后一次随访日期（根据地点，中位随访时间为 6.0-9.8 年）。为所有癌症和每种癌症分别构建了 Kaplan-Meier 曲线。使用 Cox 回归估计年龄调整后的风险比（HR）。结局是全因死亡率。所有癌症的最高四分位数硒水平与死亡率降低相关（HR=0.66；95%CI 0.49-0.88；P=0.005）。最高四分位数锌水平也与死亡率降低相关（HR=0.55；95%CI 0.41-0.75；P=0.0001）。相比之下，最高四分位数铜水平与死亡率升高相关（HR=1.91；95%CI 1.56-2.08；P=0.0001）。三种血清元素——硒、锌和铜——与不同类型癌症的预后相关。
