• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

S-(N-Methylcarbamoyl)-N-acetylcysteine: a urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC 3051) in mouse, rat and man.

作者信息

Kestell P, Gledhill A P, Threadgill M D, Gescher A

出版信息

Biochem Pharmacol. 1986 Jul 15;35(14):2283-6. doi: 10.1016/0006-2952(86)90452-1.

DOI:10.1016/0006-2952(86)90452-1
PMID:3729985
Abstract
摘要

相似文献

1
S-(N-Methylcarbamoyl)-N-acetylcysteine: a urinary metabolite of the hepatotoxic experimental antitumour agent N-methylformamide (NSC 3051) in mouse, rat and man.S-（N-甲基氨基甲酰基）-N-乙酰半胱氨酸：小鼠、大鼠和人类中肝毒性实验性抗肿瘤药物N-甲基甲酰胺（NSC 3051）的一种尿液代谢产物。
Biochem Pharmacol. 1986 Jul 15;35(14):2283-6. doi: 10.1016/0006-2952(86)90452-1.
2
Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite.
J Pharmacol Exp Ther. 1987 Jul;242(1):312-9.
3
Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.细胞色素P450同工酶CYP2E1催化的N-甲基甲酰胺的代谢氧化与解毒作用。
Mol Pharmacol. 1992 Feb;41(2):259-66.
4
N-alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans.N-烷基甲酰胺可被来自啮齿动物和人类的肝脏微粒体代谢为N-烷基氨基甲酰化物质。
Chem Res Toxicol. 1990 Jul-Aug;3(4):357-62. doi: 10.1021/tx00016a014.
5
Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes.肝毒素N-甲基甲酰胺及相关甲酰胺在小鼠肝细胞中的细胞毒性与代谢
Toxicol Appl Pharmacol. 1988 Aug;95(1):162-70. doi: 10.1016/s0041-008x(88)80015-2.
6
Identification of N-acetyl-S-(N-methylcarbamoyl)cysteine, a human metabolite of N,N-dimethylformamide and N-methylformamide.N-乙酰-S-（N-甲基氨基甲酰）半胱氨酸的鉴定，N，N-二甲基甲酰胺和N-甲基甲酰胺的一种人体代谢产物。
J Chromatogr. 1987 Mar 6;414(2):399-404. doi: 10.1016/0378-4347(87)80064-6.
7
Gas chromatographic method for the determination of N-acetyl-S-(N-methylcarbamoyl)cysteine, a metabolite of N,N-dimethylformamide and N-methylformamide, in human urine.气相色谱法测定人尿中N，N-二甲基甲酰胺和N-甲基甲酰胺的代谢产物N-乙酰-S-（N-甲基氨基甲酰基）半胱氨酸
J Chromatogr. 1988 Oct 14;431(2):361-8. doi: 10.1016/s0378-4347(00)83104-7.
8
Simultaneous determination of N-hydroxymethyl-N-methylformamide, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl)cystein in urine samples from workers exposed to N,N-dimethylformamide by liquid chromatography-tandem mass spectrometry.采用液相色谱-串联质谱法同时测定接触N,N-二甲基甲酰胺工人尿液样本中的N-羟甲基-N-甲基甲酰胺、N-甲基甲酰胺和N-乙酰-S-(N-甲基氨基甲酰)半胱氨酸。
J Pharm Biomed Anal. 2005 Feb 7;37(1):165-70. doi: 10.1016/j.jpba.2004.10.001.
9
N-methylformamide: antitumour activity and metabolism in mice.N-甲基甲酰胺：小鼠体内的抗肿瘤活性及代谢
Br J Cancer. 1982 Jun;45(6):843-50. doi: 10.1038/bjc.1982.136.
10
An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides.
J Pharmacol Exp Ther. 1987 Jan;240(1):265-70.

引用本文的文献

1
Thioredoxin reductase is inhibited by the carbamoylating activity of the anticancer sulfonylhydrazine drug laromustine.硫氧还蛋白还原酶可被抗癌磺酰肼药物拉罗司汀的氨甲酰化活性抑制。
Mol Cell Biochem. 2012 Nov;370(1-2):199-207. doi: 10.1007/s11010-012-1411-y. Epub 2012 Aug 5.
2
Metabolism and hepatotoxicity of N,N-dimethylformamide, N-hydroxymethyl-N-methylformamide, and N-methylformamide in the rat.大鼠体内N，N-二甲基甲酰胺、N-羟甲基-N-甲基甲酰胺和N-甲基甲酰胺的代谢及肝毒性
Arch Toxicol. 1994;68(5):291-5. doi: 10.1007/s002040050071.
3
N-methyl antitumour agents. A distinct class of anticancer drugs?
N-甲基抗肿瘤药物。一类独特的抗癌药物？
Cancer Chemother Pharmacol. 1987;19(2):91-102. doi: 10.1007/BF00254559.
4
Comparative hepatotoxicity and metabolism of N-methylformamide in rats and mice.N-甲基甲酰胺在大鼠和小鼠体内的比较肝毒性及代谢
Arch Toxicol. 1988;62(2-3):167-76. doi: 10.1007/BF00570135.