[中亚黑蝎Orthochirus scrobiculosus毒液中神经毒素Os-1的完整氨基酸序列]
[Complete amino acid sequence of neurotoxin Os-1 from the venom of the Central Asian black scorpion Orthochirus scrobiculosus].
作者信息
Potapenko N A, Volkova T M, Garsia A F, Galkina T G, Dulubova I E
出版信息
Bioorg Khim. 1986 May;12(5):581-90.
PMID:3730007
Abstract
The neurotoxin Os-1 from the venom of the Central Asian scorpion Orthochirus scrobiculosus possesses a high paralytic activity against mice. This neurotoxin was subjected to tryptic, chymotryptic and BrCN cleavages and its total amino acid sequence was established. It was shown that neurotoxin Os-1 consists of 66 amino acid residues an contains four disulfide bonds.
摘要
来自中亚蝎子Orthochirus scrobiculosus毒液的神经毒素Os-1对小鼠具有很高的麻痹活性。该神经毒素经胰蛋白酶、胰凝乳蛋白酶和溴化氰裂解，并确定了其完整氨基酸序列。结果表明，神经毒素Os-1由66个氨基酸残基组成，含有四个二硫键。
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