[来自中亚蝎子以色列金蝎毒液的神经毒素]
[Neurotoxins from the venom of the Central Asian scorpion Buthus eupeus].
作者信息
Volkova T M, Garsia A F, Telezhinskaia I N, Potapenko N A, Grishin E V
出版信息
Bioorg Khim. 1985 Nov;11(11):1445-56.
PMID:4091860
Abstract
Three main polypeptide neurotoxins M9, M10, M14, possessing paralytic activity in mice, have been isolated from the venom of the Central Asian scorpion Buthus eupeus. The amino acid composition of these toxins was determined. Toxins M9 and M14 were digested with trypsin, chymotrypsin, Staphylococcus aureus proteinase and cleaved with BNPS-skatole. The complete amino acid sequences of the toxins M9 and M14 were established.
摘要
已从中亚蝎子东亚钳蝎的毒液中分离出三种主要的具有小鼠麻痹活性的多肽神经毒素M9、M10、M14。测定了这些毒素的氨基酸组成。用胰蛋白酶、糜蛋白酶、金黄色葡萄球菌蛋白酶对毒素M9和M14进行消化，并用BNPS-粪臭素进行切割。确定了毒素M9和M14的完整氨基酸序列。
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