Department of Applied Science and Technology (DISAT), Politecnico di Torino, Turin, Italy.
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nürnberg, Erlangen, Germany.
J Biomed Mater Res A. 2023 Nov;111(11):1692-1709. doi: 10.1002/jbm.a.37578. Epub 2023 Jun 10.
In this work, composite electrospun fibers containing innovative bioactive glass nanoparticles were produced and characterized. Poly(ε-caprolactone), benign solvents, and sol-gel B- and Cu-doped bioactive glass powders were used to fabricate fibrous scaffolds. The retention of bioactive glass nanoparticles in the polymer matrix, the electrospinnability of this novel solution and the obtained electrospun composites were extensively characterized. As a result, composite electrospun fibers characterized by biocompatibility, bioactivity, and exhibiting overall properties adequate for both hard and soft tissue engineering applications, have been produced. The addition of these bioactive glass nanoparticles was, indeed, able to impart bioactive properties to the fibers. Cell culture studies show promising results, demonstrating proliferation and growth of cells on the composite fibers. Wettability, degradation rate, and mechanical performance were also tested and are in line with previous results.
本工作制备并表征了含有创新型生物活性玻璃纳米粒子的复合电纺纤维。使用聚(ε-己内酯)、良性溶剂和溶胶-凝胶法 B 和 Cu 掺杂的生物活性玻璃粉末来制备纤维支架。研究了生物活性玻璃纳米粒子在聚合物基质中的保留情况、这种新型溶液的可纺性以及获得的电纺复合材料的广泛特性。结果表明，成功制备了具有生物相容性、生物活性且整体性能适合硬组织和软组织工程应用的复合电纺纤维。这些生物活性玻璃纳米粒子的添加确实能够赋予纤维生物活性。细胞培养研究结果表明，细胞在复合纤维上增殖和生长。润湿性、降解速率和机械性能也进行了测试，结果与之前的结果一致。
