Shao Huifeng, Zhang Tao, Gong Youping, He Yong
School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou, 310018, China.
State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Adv Healthc Mater. 2023 Oct;12(26):e2300932. doi: 10.1002/adhm.202300932. Epub 2023 Jun 20.
Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver-containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver-containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver-containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors' perspectives on the challenges and future directions of silver in commercialization and in-depth research.
生物材料引起的细菌感染是植入物临床治疗中一个非常严重的问题。抗生素耐药性的出现促使其他抗菌剂取代传统抗生素。银作为一种抗菌候选材料正在迅速发展，以抑制骨感染，因为它具有高抗菌时效性、高抗菌效率和不易产生细菌耐药性等显著优点。然而，银具有很强的细胞毒性，会引起炎症反应和氧化应激，从而破坏组织再生，使得含银生物材料的应用极具挑战性。本文综述了银在生物材料中的应用，重点关注以下三个问题：1）如何确保银具有优异的抗菌性能且不易产生细菌耐药性；2）如何选择合适的方法将银与生物材料结合；3）如何使含银生物材料在硬组织植入物方面有进一步研究。在简要介绍之后，讨论集中在含银生物材料的应用上，重点是银对生物材料的物理化学性质、结构性质和生物学性质的影响。最后，综述以作者对银在商业化和深入研究方面的挑战及未来方向的观点作为结论。
