诱导多巴胺受体超敏后大鼠的选择性注意力缺陷。

A selective attention deficit in the rat following induced dopamine receptor supersensitivity.

作者信息

Crider A, Blockel L, Solomon P R

出版信息

Behav Neurosci. 1986 Jun;100(3):315-9. doi: 10.1037//0735-7044.100.3.315.

DOI:10.1037//0735-7044.100.3.315

Abstract

In the blocking paradigm, prior training to one conditioned stimulus (CSA) blocks the ability to attend to a second conditioned stimulus (CSB) when the two form a compound (CSAB) in subsequent training. Blocking is an associative process by which animals learn to ignore CSB because it contains no new information regarding the reinforcing event. In Experiment 1, dopamine (DA) receptor supersensitivity was induced in rats by prolonged pretreatment with haloperidol. The animals with DA receptor supersensitivity failed to show blocking by responding equivalently to both elements of the CSAB compound. This effect was replicated in Experiment 2, which also tested for an arousal interpretation of disrupted blocking by introducing a novel stimulus following training. Supersensitive rats were no more responsive to this novel stimulus than were control animals, which supports a selective attention deficit interpretation of disrupted blocking with DA receptor supersensitivity. This attentional deficit resembles behavioral perseverations induced by DA agonists.

摘要

在阻断范式中，对一种条件刺激（CSA）的预先训练会阻碍动物在后续训练中对第二种条件刺激（CSB）的注意能力，当这两种刺激形成复合刺激（CSAB）时。阻断是一种联想过程，通过这个过程动物学会忽略CSB，因为它不包含关于强化事件的新信息。在实验1中，通过用氟哌啶醇进行长时间预处理诱导大鼠的多巴胺（DA）受体超敏。具有DA受体超敏的动物未能通过对CSAB复合刺激的两个成分做出同等反应来表现出阻断。这一效应在实验2中得到了重复，实验2还通过在训练后引入新刺激来测试对阻断破坏的唤醒解释。超敏大鼠对这种新刺激的反应并不比对照动物更敏感，这支持了对DA受体超敏导致的阻断破坏的选择性注意缺陷解释。这种注意缺陷类似于DA激动剂诱导的行为持续。