Sagvolden T, Holth P
Behav Neurosci. 1986 Jun;100(3):330-6. doi: 10.1037//0735-7044.100.3.330.
This study was conducted to examine effects of medial and dorsolateral septal lesions on acquisition by using a modified autoshaping procedure. The results showed that following medial septal lesions, lever-pressing responses had long latencies and were fewer than following either dorsolateral septal lesions or control operations. However, during later sessions, the rats with medial septal lesions started to press. The long response latencies and low response rates shown initially by rats with medial septal lesions may have been due to delayed classical conditioning. Following medial septal lesions, the acetylcholinesterase activities of the different subdivisions of the hippocampus correlated positively with the number of lever-press responses emitted during Session 1. The group with dorsolateral septal lesions acquired the task just as fast as the control group and showed higher response rates than the other two groups during the final sessions. The latter result may be ascribed to generally increased locomotor activity.
本研究旨在通过使用改良的自动成形程序来检验内侧和背外侧隔区损伤对习得的影响。结果表明，内侧隔区损伤后，杠杆按压反应的潜伏期较长，且比背外侧隔区损伤或对照手术组的反应少。然而，在随后的实验阶段，内侧隔区损伤的大鼠开始按压。内侧隔区损伤的大鼠最初表现出的长反应潜伏期和低反应率可能是由于经典条件反射延迟所致。内侧隔区损伤后，海马不同亚区的乙酰胆碱酯酶活性与第1阶段发出的杠杆按压反应数量呈正相关。背外侧隔区损伤组完成任务的速度与对照组一样快，并且在最后阶段的反应率高于其他两组。后一结果可能归因于总体运动活动的增加。
