László A, Petri I, Ilyés M
Acta Paediatr Hung. 1986;27(1):23-9.
ADCC reaction (antibody dependent cellular cytotoxicity), ADCC capacity and ADCC steroid sensitivity examinations were performed in 20 children with tumorous or haematological diseases, 10 children with autoimmune diseases, and appropriate controls, in order to establish the killer function and steroid sensitivity. In the above diseases a study was also made of the correlation of the individual reactions with the duration of steroid therapy. The two patient groups did not exhibit a significant difference from the controls as concerns the ADCC reaction and ADCC capacity. In the group of tumorous or malignant haematological diseases the steroid sensitivity behaved in a different way, with sensitivity in 45%, moderate sensitivity in 20%, and steroid resistance in 35% of the patients. Steroid inhibition of the ADCC reaction was significantly decreased in the group of autoimmune patients. There was no correlation between ADCC reaction and ADCC steroid sensitivity or resistance in either group, and thus the ADCC steroid resistance or sensitivity and lymphocyte killer function proved to be independent. No correlation was found between the steroid sensitivity or resistance and the duration of steroid treatment.
对20名患有肿瘤或血液疾病的儿童、10名患有自身免疫性疾病的儿童以及适当的对照组进行了抗体依赖细胞介导的细胞毒性反应（ADCC反应）、ADCC能力和ADCC类固醇敏感性检查，以确定杀伤功能和类固醇敏感性。对于上述疾病，还研究了个体反应与类固醇治疗持续时间之间的相关性。在ADCC反应和ADCC能力方面，这两组患者与对照组相比没有显著差异。在肿瘤或恶性血液疾病组中，类固醇敏感性表现不同，45%的患者敏感，20%的患者中度敏感，35%的患者对类固醇耐药。自身免疫性疾病组中，ADCC反应的类固醇抑制作用显著降低。两组中ADCC反应与ADCC类固醇敏感性或耐药性之间均无相关性，因此ADCC类固醇耐药性或敏感性与淋巴细胞杀伤功能被证明是独立的。未发现类固醇敏感性或耐药性与类固醇治疗持续时间之间存在相关性。
