Kaganov B S, Zimin Iu I, Uchaĭkin V F, Saidov M Z, Sorokin A M
Biull Eksp Biol Med. 1984 Dec;98(12):700-2.
Antibody-dependent cell-mediated cytotoxicity (ADCC) and in-vitro effect of interferon (IF) on the K cell activity was investigated in children with chronic hepatitis B (CHB) and normal donors. The ADCC in CHB was significantly decreased under normal values. The low K cell activity in CHB might determine inadequate elimination of infected liver cells and continuation of hepatitis B virus replication. IF in vitro significantly stimulated the ADCC of normal blood donors but was unable to significantly increase the ADCC of CHB patients. The in-vitro stimulation of the ADCC of normal donors by IF might be a phenomenon due to an increase of the adult K cell cytotoxic potential and/or activation of pre-K cell maturation. The lack of in-vitro augmentation of the ADCC of CHB patients by IF might result from the decreased quantity of K cells of pre-K cells in the peripheral blood and/or their low susceptibility to the stimulating effect of IF.
在慢性乙型肝炎（CHB）患儿和正常供体中研究了抗体依赖性细胞介导的细胞毒性（ADCC）以及干扰素（IF）对K细胞活性的体外作用。CHB患者的ADCC显著低于正常值。CHB患者K细胞活性较低可能导致受感染肝细胞清除不足以及乙肝病毒复制持续。IF在体外显著刺激正常献血者的ADCC，但无法显著提高CHB患者的ADCC。IF对正常供体ADCC的体外刺激可能是由于成人K细胞细胞毒性潜能增加和/或前K细胞成熟激活所致。IF缺乏对CHB患者ADCC的体外增强作用可能是由于外周血中前K细胞数量减少和/或它们对IF刺激作用的敏感性较低。
