Maloof Alexander George, Pavic Nicholas Vlado, Zhang Shane, Chan Weng Onn, Bacchi Stephen, Qian Go Christopher Ze
Faculty of Medicine, University of New South Wales, Sydney, Australia.
College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Retina. 2025 May 15;45(9):1780-9. doi: 10.1097/IAE.0000000000004533.
Retinal temporal vessel angles (TVA) could function as a clinical marker to reflect the structural and functional integrity of the macular region. We aimed to systematically search and appraise all literature investigating the association between temporal vessel angles (TVA) and familial exudative vitreoretinopathy (FEVR).
A systematic review was conducted in accordance with the PRISMA guidelines. We identified articles examining the association between TVA and FEVR by systematically searching PubMed, Medline, EMBASE and SCOPUS, on January 15, 2024. Additional studies were located through hand searching and content area expert contributions. The methodological quality of the included studies was evaluated using the Newcastle Ottawa Scale.
We identified 767 papers in the initial search. After screening 333 papers, three papers were included in the review. In all three studies, the FEVR group had a significantly smaller temporal retinal vessel angle compared to healthy full-term infants or infants with retinopathy of prematurity. Narrower temporal vessel angles have been found to be associated with the presence and progression of FEVR as compared to normal controls. No consensus about the normal threshold angle has been reached.
These data suggest that TVA measurement may serve as a clinical biomarker for the progression of FEVR. Thus, this correlation underscores the importance of TVA as a diagnostic and prognostic tool, potentially facilitating earlier intervention and more tailored treatment strategies. A standardized method of measuring TVA will enable a better understanding of its association with FEVR severity.
视网膜颞侧血管角度（TVA）可作为一种临床标志物，以反映黄斑区的结构和功能完整性。我们旨在系统检索和评估所有研究颞侧血管角度（TVA）与家族性渗出性玻璃体视网膜病变（FEVR）之间关联的文献。
按照PRISMA指南进行系统评价。我们于2024年1月15日通过系统检索PubMed、Medline、EMBASE和SCOPUS来确定研究TVA与FEVR之间关联的文章。通过手工检索和内容领域专家提供信息找到了更多研究。使用纽卡斯尔渥太华量表评估纳入研究的方法学质量。
在初步检索中我们确定了767篇论文。筛选333篇论文后，3篇论文被纳入本综述。在所有三项研究中，与健康足月儿或早产儿视网膜病变患儿相比，FEVR组的颞侧视网膜血管角度明显更小。与正常对照组相比，已发现较窄的颞侧血管角度与FEVR的存在和进展相关。尚未就正常阈值角度达成共识。
这些数据表明，TVA测量可能作为FEVR进展的临床生物标志物。因此，这种相关性强调了TVA作为诊断和预后工具的重要性，可能有助于早期干预和更具针对性的治疗策略。一种标准化的TVA测量方法将有助于更好地理解其与FEVR严重程度的关联。
